Colorectal / Breast cancer: Recommended dose: 1250 mg/m²  po bid (morning and evening; equivalent to 2500 mg/m ² total daily dose) x 2 weeks followed by a 1-week rest period given as 3-week cycles. Tablets should be swallowed with water within 30 minutes after a meal. In combination with docetaxel, the recommended dose of XELODA is 1250 mg/m²  bid x 2 weeks followed by a 1-week rest period, combined with docetaxel at 75 mg/m² as a 1-hour intravenous infusion every 3 weeks. 

Maintenance dose: Subsequent dose adjustment is recommended as outlined in the package insert if a patient develops a grade 2 to 4 adverse event. SEE PACKAGE INSERT FOR DOSAGE MODIFICATIONS BASED ON TOXICITY LEVELS.