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Infection

Wound infections  Possible therapeutic alternatives
Wound: Infected, post-op or trauma, without sepsis. (Not Gastrointestinal tract or female genital tract.) Common pathogens
Uncomplicated (mild or moderate)
Bactrim DS orally twice daily OR
Cephalexin 500mg orally 4 times daily OR
Augmentin 875/125 mg orally twice daily OR500/125mg three times daily or
Augmentin XR* 1000/62.5 mg 2 tablets orally twice daily  OR

*AUGMENTIN XR is contraindicated in patients with a creatinine clearance of < 30 mL/min. and in hemodialysis patients.
Doxycycline 100mg orally twice daily OR
Clindamycin  300mg to 450mg orally four times daily
Complicated (Severe)
Ticarcillin-clavulanic acid  3.1 grams  IV every 6 hours OR
Piperacillin-tazobactam
3.375 grams IV every 6 hours OR
Ertapenem
1 gram q24h

PLUS
Vancomycin 1 gram  ivpb q12h (patient-specific dosing required) 
Wound infection + sepsis. (does not include surgery involving GI or female genital tract) Common pathogens
Ampicillin-sulbactam 1.5 - 3 grams IV every 6 hours  OR
Ticarcillin-clavulanic acid  3.1 grams  IV every 6 hours OR
Piperacillin-tazobactam 3.375 grams IV every 6 hours OR
Cefazolin 1 gram  IV every 8 hours.
Postop wound (surgery involving gastrointestinal tract or female genital tract)  (all regimens must cover anaerobes) Common pathogens
Piperacillin-tazobactam 3.375 grams IV every 6 hours OR
Ticarcillin-clavulanic acid  3.1grams IV every 6 hours  OR
Ampicillin-sulbactam 1.5-3g ivpb q6h OR
[ (Cefotaxime 1g ivpb q8h or Ceftriaxone1-2g ivpb q24h ) +  Metronidazole 500mg ivpb q6-8h]  OR
Imipenem 500mg ivpb q6h.

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References - Infectious Disease Section

Infectious Disease References

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
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