GlobalRPh Website News - David McAuley, Pharm.D.



News Item

Sept 22, 2016 Several updates will be released before the end of the year. 

1] Drug tables:
Several new additions were added to our drug tables including new drug releases of 2016. A new desktop app will be created in the coming months to help quickly navigate the various tables.  Example - opioid induced constipation --> select GI --> Laxatives --> entire table listed and separated by standard agents (for constipation) and newer agents for OIC --> click on a single drug to review the abbreviated monograph. Newer entries will also have direct links to the most recent package insert.

2] Medical Terminology
Globalrph currently has one of the most popular medical terminology sections on the web.   We recently added TWENTY practice exams.  Also check out our new word building reference.  We have already received glowing reviews for this new section from teachers throughout the country.

3] Intravenous Dilutions:
We are in the process of reviewing all of the current monographs to make sure stability data reflects the current package insert.  In the past few years, drugs that have been available for years have had their stability data revised.  There are several  reasons for this trend including lack of sufficient data to support previous recommendations or the availability of new studies that contradicts previous data. In many cases, the stability of a particular drug has been shortened. Also 7 new entries will be added next week.

Have an idea for a new program..... let me know....

4] Connection issues:
We have a little under 1 million users. So far there has been only 6 reports of possible page loading issues or printing issues. The few sites that reported issues, also had problems with other sites.


1] Install an alternative browser that is used for viewing outside
clinically-related websites: e.g Firefox or Google Chrome.
Performance/loading is improved SIGNIFICANTLY.

Modify Internet Explorer settings:
[ 2 ] Change the browser security settings for the internet from
medium risk to HIGH risk (e.g. greater security).


[3 ] Disable 'active scripting':
Internet explorer:
Tools > security > internet> custom level > scroll to bottom of menu and change active scripting from enable to [disable].

Let me know how this works for you.....




News Item

November 24, 2015 Based on input from one of our visitors (below), a new vancomycin program was created:

Loren Trager, PharmD, BCPS, CDE
Advanced Practice Pharmacist
Tuba City Regional Health Care Corporation
Tuba City, AZ

This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained.  An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.

I also updated our current trough calculator to also generate an estimated vancomycin kel value based on the creatinine clearance.  Use this program if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate - link to new program.)
April 29, 2015 A P4 student from the University of Illinois at Chicago has created a  'Warfarin and NOAC Conversion Reference'  that he would like to share:
[Novel anticoagulant (NOAC) drugs conversion]

Michael haas



News Item

Sept 14, 2014
August 3, 2014
June 10, 2014 New calculators/tools have been released that focus on the latest cholesterol treatment protocols as well as the calculation of the estimated 10 year and lifetime risks for atherosclerotic cardiovascular disease  (ASCVD).  Actually much of the work for these new programs was completed in 2013, however, the final development was wrapped up this past week.
May 13, 2014
  1. Code blue (ACLS) cheat sheet was created.
  2. Alteplase calculator (MI, Stroke, PE).
  3. Oxalate Content Calc -  Lists the oxalate content of multiple food items to help manage overall oxalate intake.
April 30, 2014 Several updates will be released in the coming weeks including significant revisions and additions to the infectious disease drug list.  A new index page was created for the infectious disease drug tables.
April 26, 2014 A quick access page was created for the multiple drug tables. It should be much easier to find the needed information.

Additional renal dosing guidelines were added for some of the less obvious agents.
February 18, 2014 Quick dosing reference added for albumin (beta app).
February 17, 2014 An extensive vancomycin dosing tool was developed by a fellow clinician to quickly generate an empiric regimen.    Additional information can be found here.   Author: Nathan Fewel, PharmD, BCPS.


November 27, 2013 An extensive pathogenic bacteria database was just released:
[Bacteria database]

In the coming weeks, a quick review of the current infectious disease section will be completed.   Also, some modifications will likely be made to the hypocalcemia calculator.

New navigation scheme:  a possible quick access tool may be created for the multiple drug tables to help facilitate the location of a specific drug category.
June 25, 2013 1]  Comments were unintentionally omitted from the Multi-CRCL calc regarding handling of underweight patients (ABW<IBW).  Omission was reported by Dr. Sudduth  -->  Heather Sudduth, PharmD, CGP, Clinical pharmacy specialist at the Richmond VAMC.

The following comments will appear in the 'Warnings' section whenever this condition is met:

[Program used ACTUAL weight in the calculation of the Cockcroft and Gault - IBW equation since it is LESS than the IBW. - Notice below that the result for this equation is the same as the Cockcroft and Gault - actual body weight]

April 13, 2013 1] Significant improvements have been made to our very popular opioid conversion calc.  Users will now be able to modify the dosing factors that are associated with methadone conversions.  We also added additional dosing schemes including the Friedman/McPherson and Fudin approaches. The Fudin equation significantly reduces the dramatic fluctuations in the converted methadone dose that can occur around the breakpoints in the most common nomograms - e.g. Ayonrinde,   Ripamonte, etc.
  • Mathematical Model For Methadone Conversion Examined:Link
  • Fudin Factor graphically compared to Ripamonte, Ayonrinde, and Mercadante - jpeg
2] Last month we created a new drug categories page that should help locate a particular drug table.

3] Site-wide search capability:
Occasionally, the large search bar at the top of page may not provide links to recently developed material.  Alternatively, users may find the Google search functionality much more effective:

Google Site Search

Custom Search
October 01, 2012 Basal Metabolic Rate (BMR) Calculators:  Several of these calculators may be particularly useful for dieters.  Just about every single MAJOR calorie/ energy equation that has been released over the last 90 years is included below.   Each calculator has a customized printout option for easy analysis. Recommendation:   Try each calculator - print out the results -  then compare!
Estimated  'Calorie'  Calculators
Harris-Benedict Equation: Estimation of total calories needed. MOST widely used equation for calculating basal metabolic rate and total calories.
Revised Harris-Benedict Equation:  The original Harris Benedict equation was revised in 1984.  This updated equation can be used to calculate the basal metabolic rate and total calories.
RESTING Metabolic Rate (RMR) : Resting Metabolic Rate Calc - This equation can be used to calculate the RESTING metabolic rate and total calories. Mifflin-St Jeor equation.
Schofield equation (BMR) : led This equation was part of the previous government guidelines to formulate RDA's and can be used to calculate the basal metabolic rate and total calories needed.
Institute of Medicine Equation- LATEST EQUATION: IOM Equation-Estimated Energy Requirement (EER) Estimation of total calories needed. This equation is behind the 2005 Dietary Guidelines for Americans and the new food pyramid, MyPyramid.

Other calculators and tools that have been added:
  1. Estimate Resting Energy Requirements in critical care patients - Ireton-Jones Equations.
  2. Calculate the amount of protein that should be consumed daily based on the latest guidelines
  3. How much daily fiber do I need???
  4. Calculate the amount of essential amino acids that are recommended in the diet
  5. Protein / Amino acid review
  6. Protein Sources (plant-based versus animal source)
  7. Calcium and Vitamin D Calculator - How much do I need?
  8. ACLS pocket guide has been updated
July 22, 2012

1.  2012 version of the Creatinine clearance multi-calc has been released.    The updated version has the following new functions:

  • New reporting function - automated output that can be copied into an electronic record.
  • GFR-EPI equation added
  • New CKD staging function added.
2. Warfarin dose prediction equation (calculator) released. 
exp [0.613 + (0.425 x BSA) - (0.0075 x age)  + (0.156 x African-American race)  + (0.216  x target INR) - (0.257 x amiodarone) + (0.108  x smokes)   + 0.0784  x  DVT/PE ]

Reference:  Gage BF, Eby C, Johnson JA, Deych E, Rieder MJ, et al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther. 2008 Sep;84(3):326-31. Epub 2008 Feb 27.

3.  Common Intravenous Cardiac Medications Calculator (Direct thrombin inhibitors, glycoprotein IIb/IIIa inhibitors.  Includes algorithm for argatroban for HIT)
July 12th, 2012

Latest updates released:

  1. New vancomycin single level analysis tool that allows the user to enter the time that has elapsed since the last dose was given. This updated version is especially useful if the current dosing schedule was not adhered to (dose was administered early or late).  Link to program.    The original program requested the time that the trough was drawn prior to the next dose. 
  2. New epidural concentration/recipe guide. Also contains a link to a pop-up calculator for non-standard concentrations of bupivacaine and/or fentanyl.
  3. A reporting function was added to the bottom of the vancomycin single level analysis tool based on feedback from a clinical pharmacist.  This section allows the user to copy a detailed note based on the previous entries and then paste it into an electronic record.
  4. New calculator:  CKD-EPI Creatinine Equation. This program was written over 2 years ago... Sorry for the late posting.
  5. A new benzodiazepine converter program was just added. Several references were reviewed in order to make sure the final equivalent dosages had ample support.
  6. Someone had reported that important entries were missing from the renal dosing list.  An old index page was mistakenly uploaded.  Please review the current list... it contains several new entries.
March 29th, 2012 We released several updates in the last couple of months including:
  1. Warfarin calculator / background information
  2. New advanced Pharmacokinetic dosing tool that allows the user to select a custom population kinetics model:  New 2012 calc.
  3. New package insert search tool.
  4. Updated Medical calculator index page.
Expect significant updates to the current web site layout.  Our last major update of the web site (page layout) was in 2007.   Our home page will be updated first and the rest of the site will use a similar layout.


News Item

September 5th, 2011 Several new drugs were added to the renal dosing sectionCheck it out....

We have also moved to a new server!   The new server has four times the capacity of our current traffic levels.   The new environment should improve page load times and errors seen with some of our programs during extremely busy periods.
April 22, 2011 Several updates were just released (See the medical calculator section). Also in the coming months, significant upgrades to the Internal Medicine - Reference section will be completed.  You will notice that all of the individual Internal medicine disciplines were added to the left column navigation section on the home page for easy access.

I will also be reviewing the potential for additional disease state management calculators... Several beta versions are currently in the development stage.

If you have any ideas for new calculators, let me know....
September 20, 2010 The Oncology dilution section has been completed.

Several new calculators will be created in the coming months...
If time permits, a few new disease state management tools will also
be released.

Fiber Analysis

Preliminary research has been completed on a new fiber analysis tool. Look
for this important release hopefully before the end of the year.  Analysis of
specific soluble fibers can impact recommendations given to patients with elevated
cholesterol levels or as general nutritional information.  More to come.....

Current tools

Soluble fiber calculator   Fiber calculator  Fiber requirement calculator

Therapeutic relevance: HIGH

The missing link in disease pathogenesis??
This topic is extremely important to not only healthcare professionals, but also the general public.  Future articles will be added to the nutrition section..... in the meantime,  please research the IMPORTANCE of the ratio  of the omega-6/omega-3 essential fatty acids.  

"Several sources of information suggest that human beings evolved on a diet with a ratio of omega-6 to omega-3 essential fatty acids (EFA) of approximately one whereas in Western diets the ratio is 15/1-16.7/1." 

"Excessive amounts of omega-6 polyunsaturated fatty acids (PUFA) and a very high omega-6/omega-3 ratio, as is found in today's Western diets, promote the pathogenesis of many diseases, including cardiovascular disease, cancer, and inflammatory and autoimmune diseases, whereas increased levels of omega-3 PUFA (a low omega-6/omega-3 ratio) exert suppressive effects. In the secondary prevention of cardiovascular disease, a ratio of 4/1 was associated with a 70% decrease in total mortality. A ratio of 2.5/1 reduced rectal cell proliferation in patients with colorectal cancer, whereas a ratio of 4/1 with the same amount of omega-3 PUFA had no effect."

Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79.


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