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Intravenous Dilution Guidelines

Thiopental Sodium (Pentothal ®)

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.    PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

D5W, NS

Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]

Intermittent IV administration:
(2 to 5% solution is recommended) .
[1-2 grams] [50 ml] [As directed]
[5 grams][100-250ml][As directed]
[10 grams] [500 ml] [As directed]

Continuous infusion:
(0.2 to 0.4% solution is recommended ) .
[1 gram] [250 ml] or
[2 grams] [500ml]

Stability / Miscellaneous

EXP: 3 days (RT); 7 days(REF).

Onset: 30-60 seconds.
Duration: 10-30 minutes.
Ultra short acting barbiturate.

Given by slow intravenous administration only.

Dosing:
Anesthesia induction (adults): 3-5 mg/kg (2.5% solution) Maintenance: 25-100mg IV as needed.

Increased intracranial pressure: 1.5 to 5 mg/kg/dose; repeat as needed to control intra-cranial pressure.

Seizures: 75 to 250mg/dose. Repeat as needed. [case study: 250 mg IV bolus followed by 80-120 mg/hr.]
Disclaimer
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.  PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
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