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Intravenous Dilution Guidelines

Sodium Chloride 3%

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.    PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

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Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]

513 meq/ 1000 ml (3%)
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Stability / Miscellaneous


Sodium (normal range): 136 to 147 meq/l.

The goal of treatment is to get the patient out of immediate danger (return sodium level to > 120 meq/l). Usually reserved for severe symptomatic hyponatremia (level usually < 115). The maximum rate of increase (sodium level) is 2 meq/L/hr. The usual rate is 0.5 to 1 meq/L/hr-- these lower rates help avoid serious CNS complications (cerebral edema, pontine myelinolysis,seizures) and/or pulmonary edema.

Always verify the infusion rate and the length of infusion based on patient weight and sodium level.

Calculation of the sodium deficit:
0.6 x weight(kg) x (desired Na+ - Actual Na+). Use 0.5 for females. Desired Na+= 120-125 meq/l.

Example: 70kg male. Na+= 110 meq/l Desired target= 125 meq/l.

[0.6 x 70kg x (125-110)= 630 meq of Na+ needed].

Amount needed to increase serum sodium level by 1 meq/l/hr= 0.6 x 70kg x 1.0= 42 meq/hr (safe rate for this patient).

3%--hypertonic saline contains 513 meq/liter.

Therefore: [desired rate per hr] / 513 x 1000 = infusion rate (ml/hr).
And the total infusion time= [total meq needed] / [meq/hr]

Desired rate= 42/513 meq x 1000= 82 ml/hr

Infusion time= [630 meq] / [42 meq/hr] = 15 hrs.

Therefore: Infuse 3% saline at 82 ml/hr for 15 hours.

Always verify the infusion rate and the length of infusion (using the calculations above) versus what is ordered.
Disclaimer
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.  PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
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