Mucolytic agent. Adult (usual): Acetaminophen poisoning: 140 mg/kg orally, followed by
17 doses of 70 mg/kg every 4 hours. Repeat dose if emesis occurs within
1 hour of administration. Therapy should continue until all doses are
administered even though the acetaminophen plasma level has dropped
below the toxic range. Alternatively: Give Acetadote ®: Loading dose:
150 mg/kg IV over 60 minutes. Maintenance dose: 50 mg/kg infused over 4
hours followed by 100 mg /kg infused over 16 hours. Note: To avoid fluid
overload in patients <40 kg and those requiring fluid restriction,
decrease volume of D5W proportionally.
Adjuvant therapy in respiratory conditions: Note:
Patients should receive bronchodilator 15 minutes prior to dose.
Inhalation, nebulization: 10% and 20%
solution. Dilute 20% solution with sodium chloride or sterile water for
inhalation. 10% solution may be used undiluted: 3-5 ml of 20% solution
or 6-10 ml of 10% solution until nebulized - given 3-4 times/day. Dosing
range: 1-10 ml of 20% solution or 2-20 ml of 10% solution every 2-6
hours. Into tracheostomy: 1-2 ml of 10% to
20% solution every 1-4 hours.
Decrease risk of contrast-induced nephropathy: (4 doses
total): 600 mg (3ml) po BID on the day before the contrast injection,
then 600 mg (3ml) in a.m. on the day of the contrast injection
(immediately before) and 600 mg (3ml) in the evening. In all cases the
patient should be well hydrated. This is particularly important in
patients with underlying renal dx or diabetes mellitus. Hydrate patient
with saline concurrently.
Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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