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Protease inhibitors
HIV-Related Drug Classes - Navigation |
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amprenavir (Agenerase ® ) |
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Protease Inhibitor.
Dosing (Adult): 1200 mg orally twice daily.
Supplied: [50, 150 mg caps. 15mg/ml oral solution.] ( large pill burden. Must warn of gastrointestinal (GI) intolerance and rash.) |
atazanavir (Reyataz ® ) |
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Protease Inhibitor.
Dosing (Adult): Antiretroviral-naive patients: 400 mg once daily with food. Antiretroviral-experienced patients: 300 mg once daily plus ritonavir 100 mg once daily with food. Coadministration with efavirenz: Antiretroviral-naive patients: It is recommended that atazanavir 300 mg plus ritonavir 100 mg be given with efavirenz 600 mg (all as a single daily dose). Administer with food. Antiretroviral-experienced patients: Recommendations have not been established. Coadministration with didanosine buffered formulations: Administer atazanavir 2 hours before or 1 hour after didanosine buffered formulations. Coadministration with tenofovir: The manufacturer recommends that atazanavir 300 mg plus ritonavir 100 mg be given with tenofovir 300 mg (all as a single daily dose). Administer with food. Supplied: Capsule: 100 mg, 150 mg, 200 mg. |
Darunavir (Prezista™) |
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Dosing (Adult): Treatment of HIV infection: Oral: 600 mg twice daily with meals. Note: Co-administration with ritonavir (100 mg twice daily) is required. Administer with food (bioavailability is increased). Coadministration with ritonavir is required. Indications: Treatment of HIV-1 infections in combination with ritonavir and other antiretroviral agents; limited to highly treatment-experienced or multiprotease inhibitor-resistant patients Supplied: Tablet: 300 mg |
fosamprenavir (Lexiva ® ) |
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Protease Inhibitor.
Dosing (Adult): Antiretroviral therapy-naive patients: Unboosted regimen: 1400 mg twice daily (without ritonavir). Ritonavir-boosted regimens: Once-daily regimen: Fosamprenavir 1400 mg plus ritonavir 200 mg once daily. Twice-daily regimen: Fosamprenavir 700 mg plus ritonavir 100 mg twice daily. Note: Also used in protease inhibitor-experienced patients. Protease inhibitor-experienced patients: Fosamprenavir 700 mg plus ritonavir 100 mg twice daily. Note: Once-daily administration is not recommended in protease inhibitor-experienced patients. Combination therapy with efavirenz (ritonavir-boosted regimen): Once-daily regimen: Fosamprenavir 1400 mg daily plus ritonavir 300 mg once daily. Twice-daily regimen: No dosage adjustment recommended for twice-daily regimen. Supplied: 700 mg tablet. |
indinavir (Crixivan ® ) |
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Protease Inhibitor.
Dosing (Adult): 800mg orally every 8 hours without food or 1200mg orally every 12 hours. (must be taken on an empty stomach). Supplied: [200, 333, and 400mg capsules]. |
Kaletra ® (Lopinavir 133 mg + Ritonavir 33.3 mg ): |
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Protease Inhibitor.
Dosing (Adult): (take with food): Therapy-naive: Lopinavir 800 mg/ritonavir 200 mg once daily or lopinavir 400 mg/ritonavir 100 mg twice daily. Therapy-experienced: Lopinavir 400 mg/ritonavir 100 mg twice daily. Note: Once-daily dosing regimen has not been evaluated with concurrent indinavir or saquinavir and should not be used with concomitant phenytoin, carbamazepine, or phenobarbital therapy. Dosage adjustment when taken with amprenavir, efavirenz. nelfinavir, or nevirapine: Lopinavir 533 mg/ritonavir 133 mg twice daily. Note: Once-daily dosing regimen should not be used when concomitantly taking amprenavir, efavirenz, nelfinavir, or nevirapine therapy. Supplied: Capsule: Lopinavir 133.3 mg and ritonavir 33.3 mg. oral soln: Lopinavir 80 mg and ritonavir 20 mg/ml. |
nelfinavir (Viracept ®) |
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Dosing (Adult):
750 mg orally three times a day or 1250mg orally twice daily. Take with
high fat meal and warn of diarrhea that usually responds to loperamide
or calcium. Supplied: [250mg tablet]. |
ritonavir (Norvir ®) |
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Protease Inhibitor.
Dosing (Adult): (Day 1): 300mg orally twice daily (Days 2-4): 400 mg orally twice daily. (Day 5): 500mg orally twice daily; (Day 6 or longer): 600mg orally twice a day. Take with food. Supplied: [100mg capsule; 80mg/ml -240ml soln] GI intolerance is a major problem and is dose-related. |
saquinavir (Fortovase ® , Invirase ®) |
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Protease Inhibitor.
Dosing (Adult): Fortovase: 1200mg orally three times a day after meals. Invirase: 600mg orally three times a day with meals. Supplied: [200mg capsule] |
tipranavir (Aptivus ® ) |
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Protease Inhibitor.
Dosing (Adult): 500 mg twice daily with a high-fat meal. Note: Coadministration with ritonavir (200 mg twice daily) is required. Supplied: 250 mg capsule. |
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Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
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