Phenobarbital - Intravenous (IV) Dilution

Phenobarbital

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Usual Diluents

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

[0 to 100 mg] [50 ml] [30 min]
[Over 100 mg] [100 ml] [30 min]

Maximum rate: 100 mg/min.
Avoid rapid I.V. administration >50 mg/minute; avoid intra-arterial injection; parenteral solutions are highly alkaline; avoid extravasation

Stability / Miscellaneous

Dosing (adults):
Alcohol withdrawal: 260 mg IV initially, followed by 130mg q30min to achieve light sedation.

Sedation: Oral, I.M.: 30-120 mg/day in 2-3 divided doses

Hypnotic: Oral, I.M., I.V., SubQ: 100-320 mg at bedtime

Preoperative sedation: I.M.: 100-200 mg 1-1.5 hours before procedure

Anticonvulsant:
Status epilepticus:
Loading dose: I.V.:
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Adults: 300-800 mg initially followed by 120-240 mg/dose at 20-minute intervals until seizures are controlled or a total dose of 1-2 g

Anticonvulsant maintenance dose: Oral, I.V.:
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Adults: 1-3 mg/kg/day in divided doses or 50-100 mg 2-3 times/day

Therapeutic range: 15 - 40 mcg/ml.