| Stability:
The reconstituted solution may be stored for up to 2 hours at room
temperature prior to further dilution; the admixed solution may be stored for up to
24 hours at
room temperature prior to intravenous infusion. Both the reconstituted solution and the admixed
solution do not need to be protected from light.
Reconstitution: dilute
40 mg vial with 10 ml normal saline.
Maximum rate: 3 mg/min.
Note: In-line filter is NOT required with the revised formulation
currently being offered by the manufacturer.
Usual dosage:
Gastroesophageal Reflux Disease with
history of Erosive Esophagitis: 40
mg IV once daily for 7 to 10 days.
Continuous
infusion:
Prevention of peptic ulcer rebleeding in high-risk patients or
endoscopic evidence of active bleeding: 80 mg IV bolus over 5-15
minutes, followed by 8 mg/hr x 72 hours (maximum). No additional benefit
found for tx > 72 hrs.
Zollinger-Ellison Syndrome:
80 mg q 8-12 hrs daily. Starting dose: 80 mg IV q12h.
Two Minute Infusion:
PROTONIX I.V. for Injection should be reconstituted with 10 mL of 0.9% Sodium Chloride
Injection, USP, per vial to a final concentration of approximately 4 mg/mL. The reconstituted
solution may be stored for up to 2 hours at room temperature prior to intravenous infusion and
does not need to be protected from light. The total volume should be administered intravenously over a period of at least 2 minutes.
Note: 80 mg (2 vials - each with a concentration of
4 mg/ml) may also be given over at least 2 minutes.
|
