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Pantoprazole
Protonix ®
Usual Diluents
NS ,  D5W ,   LR
Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]
[40 mg] [100 ml] [15-30 min]

Bolus dose:
[80 mg] [80 ml] [5 minutes]
(Total volume = 100ml)

Continuous infusion (8 mg/hr)
[80 mg] [80 ml] [ 10 ml/hr]
(Total volume = 100ml)

Minimum dilution: Diluted vial (4 mg/ml) can be administered over at least 2 minutes.
Stability / Miscellaneous
Stability: The reconstituted solution may be stored for up to 2 hours at room temperature prior to further dilution; the admixed solution may be stored for up to 24 hours at room temperature prior to intravenous infusion. Both the reconstituted solution and the admixed solution do not need to be protected from light. 

Reconstitution: dilute 40 mg vial with 10 ml normal saline. 
Maximum rate
: 3 mg/min. 
 

Note: In-line filter is NOT required with the revised formulation currently being offered by the manufacturer. 

Usual dosage:  
Gastroesophageal Reflux Disease with history of Erosive Esophagitis:
40 mg IV once daily for 7 to 10 days. 

Continuous infusion: Prevention of peptic ulcer rebleeding  in high-risk patients or endoscopic evidence of active bleeding: 80 mg IV bolus over 5-15 minutes, followed by 8 mg/hr x 72 hours (maximum). No additional benefit found for tx > 72 hrs.

Zollinger-Ellison Syndrome: 80 mg q 8-12 hrs daily. Starting dose: 80 mg IV q12h.

Two Minute Infusion:
PROTONIX I.V. for Injection should be reconstituted with 10 mL of 0.9% Sodium Chloride Injection, USP, per vial to a final concentration of approximately 4 mg/mL. The reconstituted solution may be stored for up to 2 hours at room temperature prior to intravenous infusion and does not need to be protected from light. The total volume should be administered intravenously over a period of at least 2 minutes. Note: 80 mg (2 vials - each with a concentration of  4 mg/ml) may also be given over at least  2 minutes.

 


 

 

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