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BROWSE topics
Ophthalmic - Mydriatics & Cycloplegics:
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Atropine (Isopto Atropine):
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| Dosing: 1-2 drops before procedure. Or 1 to 4 times daily. | ||||||
Cyclopentolate (Cyclogyl ®)
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CLINICAL PHARMACOLOGY This anticholinergic preparation blocks the responses of the sphincter muscle of the iris and the accommodative muscle of the ciliary body to cholinergic stimulation, producing pupillary dilation (mydriasis) and paralysis of accommodation (cycloplegia). It acts rapidly, but has a shorter duration than atropine. Maximal cycloplegia occurs within 25 to 75 minutes after instillation. Complete recovery of accommodation usually takes 6 to 24 hours. Complete recovery from mydriasis in some individuals may require several days. Heavily pigmented irides may require more doses than lightly pigmented irides. INDICATIONS AND USAGE Cyclopentolate hydrochloride ophthalmic solution is used to produce mydriasis and cycloplegia. CONTRAINDICATIONS AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution) should not be used when untreated narrow-angle glaucoma, or untreated anatomically narrow angles are present, or if the patient is hypersensitive to any component of this preparation DOSAGE AND ADMINISTRATION Adults: Instill one or two drops of 1% or 2% solution in the eye which may be repeated in five to ten minutes if necessary. Complete recovery usually occurs in 24 hours. Complete recovery from mydriasis in some individuals may require several days. Children: Instill one or two drops of 1% or 2% solution in the eye which may be repeated five to ten minutes later by a second application of 1% solution if necessary. HOW SUPPLIED AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution, USP) is a sterile ophthalmic solution supplied in white opaque plastic dropper bottles as follows: AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution USP, 1%) 2 mL NDC 17478-100-20 5 mL NDC 17478-100-10 15 mL NDC 17478-100-12 AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution USP, 2%) 2 mL NDC 17478-097-20 5 mL NDC 17478-097-10 15 mL NDC 17478-097-12 |
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Homatropine (Isopto Homatropine):
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| Dosing: 1-2 drops before procedure. Or 2 to 3 times daily. | ||||||
Phenylephrine (Mydfrin ®)
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| mydriasis only. Dosing:1-2 drops before procedure. | ||||||
Tropicamide (Mydriacyl ®)
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CLINICAL PHARMACOLOGY This anticholinergic preparation blocks the responses of the sphincter muscle of the iris and the ciliary muscle to cholinergic stimulation, dilating the pupil (mydriasis). The stronger preparation (1%) also paralyzes accommodation. This preparation acts in 15-30 minutes and the duration of activity is approximately 3-8 hours. Complete recovery from mydriasis in some individuals may require 24 hours. The weaker strength may be useful in producing mydriasis with only slight cycloplegia. Heavily pigmented irides may require more doses than lightly pigmented irides. INDICATIONS AND USAGE For mydriasis and cycloplegia for diagnostic procedures. CONTRAINDICATIONS Contraindicated in persons showing hypersensitivity to any component of this preparation. DOSAGE AND ADMINISTRATION For refraction, instill one or two drops of 1% solution in the eye(s), repeated in five minutes. If patient is not seen within 20 to 30 minutes, an additional drop may be instilled to prolong mydriatic effect. For examination of fundus, instill one or two drops of 0.5% solution 15 to 20 minutes prior to examination. Individuals with heavily pigmented irides may require higher strength or more doses. Mydriasis will reverse spontaneously with time, typically in 4 to 8 hours. However, in some cases, complete recovery may take up to 24 hours. HOW SUPPLIED TROPICACYL® Tropicamide Ophthalmic Solution USP, 0.5% and 1% are supplied as sterile solutions in plastic dropper bottles. 0.5% NDC 17478-101-12 (15 mL) 1% NDC 17478-102-12 (15 mL) 1% NDC 17478-102-20 (2 mL) STORAGE Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Do not refrigerate or store at high temperatures. Keep container tightly closed |
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