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Ophthalmic - Mydriatics & Cycloplegics:

Ophthalmic agents - Home Page
Atropine (Isopto Atropine) Cyclopentolate (Cyclogyl ®)
Homatropine (Isopto Homatropine) Phenylephrine (Mydfrin ®)
Tropicamide (Mydriacyl ®)  

Atropine (Isopto Atropine): top of page

 Dosing: 1-2 drops before procedure. Or 1 to 4 times daily.

Cyclopentolate (Cyclogyl ®)  top of page

CLINICAL PHARMACOLOGY
This anticholinergic preparation blocks the responses of the sphincter muscle of the iris and the accommodative muscle of the ciliary body to cholinergic stimulation, producing pupillary dilation (mydriasis) and paralysis of accommodation (cycloplegia). It acts rapidly, but has a shorter duration than atropine. Maximal cycloplegia occurs within 25 to 75 minutes after instillation. Complete recovery of accommodation usually takes 6 to 24 hours. Complete recovery from mydriasis in some individuals may require several days. Heavily pigmented irides may require more doses than lightly pigmented irides.

INDICATIONS AND USAGE
Cyclopentolate hydrochloride ophthalmic solution is used to produce mydriasis and cycloplegia.

CONTRAINDICATIONS
AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution) should not be used when untreated narrow-angle glaucoma, or untreated anatomically narrow angles are present, or if the patient is hypersensitive to any component of this preparation

DOSAGE AND ADMINISTRATION
Adults: Instill one or two drops of 1% or 2% solution in the eye which may be repeated in five to ten minutes if necessary. Complete recovery usually occurs in 24 hours. Complete recovery from mydriasis in some individuals may require several days. Children: Instill one or two drops of 1% or 2% solution in the eye which may be repeated five to ten minutes later by a second application of 1% solution if necessary.

HOW SUPPLIED
AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution, USP) is a sterile ophthalmic solution supplied in white opaque plastic dropper bottles as follows:

AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution USP, 1%)
2 mL NDC 17478-100-20
5 mL NDC 17478-100-10
15 mL NDC 17478-100-12

AK-PENTOLATE™ (Cyclopentolate Hydrochloride Ophthalmic Solution USP, 2%)
2 mL NDC 17478-097-20
5 mL NDC 17478-097-10
15 mL NDC 17478-097-12

Homatropine (Isopto Homatropine): top of page

 Dosing: 1-2 drops before procedure. Or 2 to 3 times daily.

Phenylephrine (Mydfrin ®)  top of page

mydriasis only. Dosing:1-2 drops before procedure.

Tropicamide (Mydriacyl ®)  top of page

CLINICAL PHARMACOLOGY
This anticholinergic preparation blocks the responses of the sphincter muscle of the iris and the ciliary muscle to cholinergic stimulation, dilating the pupil (mydriasis). The stronger preparation (1%) also paralyzes accommodation. This preparation acts in 15-30 minutes and the duration of activity is approximately 3-8 hours. Complete recovery from mydriasis in some individuals may require 24 hours. The weaker strength may be useful in producing mydriasis with only slight cycloplegia. Heavily pigmented irides may require more doses than lightly pigmented irides.


INDICATIONS AND USAGE
For mydriasis and cycloplegia for diagnostic procedures.


CONTRAINDICATIONS
Contraindicated in persons showing hypersensitivity to any component of this preparation.

DOSAGE AND ADMINISTRATION
For refraction, instill one or two drops of 1% solution in the eye(s), repeated in five minutes. If patient is not seen within 20 to 30 minutes, an additional drop may be instilled to prolong mydriatic effect. For examination of fundus, instill one or two drops of 0.5% solution 15 to 20 minutes prior to examination. Individuals with heavily pigmented irides may require higher strength or more doses. Mydriasis will reverse spontaneously with time, typically in 4 to 8 hours. However, in some cases, complete recovery may take up to 24 hours.


HOW SUPPLIED
TROPICACYL® Tropicamide Ophthalmic Solution USP, 0.5% and 1% are supplied as sterile solutions in plastic dropper bottles.

0.5% NDC 17478-101-12 (15 mL)
1% NDC 17478-102-12 (15 mL)
1% NDC 17478-102-20 (2 mL)


STORAGE
Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Do not refrigerate or store at high temperatures. Keep container tightly closed

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.
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