Nucleoside Reverse Transcriptase Inhibitors (NRTI's)

HIV-Related Drug Classes Navigation
	Anti-HIV Drug Classes (Home)

abacavir (Ziagen ®)

Dosing (Adults): The recommended oral dose of ZIAGEN for adults is 600 mg daily, administered as either 300 mg twice daily or 600 mg once daily, in combination with other antiretroviral agents. Warn about hypersensitivity reactions which can be lethal with rechallenge.

Atripla™ (Efavirenz, emtricitabine, and tenofovir)

Dosing (Adults): Oral: One tablet once daily to be taken on an empty stomach (at bedtime is recommended).

Renal Dosing: — Moderate-to-severe renal impairment (CrCl <50 mL/minute): Use not recommended.

Admin: Should be taken on an empty stomach, normally at bedtime to increase gastrointestinal tolerance and
decrease nervous system manifestations.

Supplied: Tablet: Efavirenz 600 mg, emtricitabine 200 mg, and tenofovir disoproxil fumarate 300 mg.

Combivir ® (AZT 300mg+150 mg lamivudine):

Dosing (Adults): 1 tablet orally twice daily.

Supplied: coated tablet (zidovudine 300mg + lamivudine 150mg). Renal failure: Use each agent independently and adjust accordingly.

didanosine (Videx ®)

Dosing (Adults): Medication must be given on an empty stomach. In order to provide adequate buffering, patients must take at least 2 of the appropriate strength tablets at each dose when using either the once daily or twice daily regimens.

Patient weight <60 kg: (Tablets): 125 mg orally twice daily or 250mg once daily or 167 mg (Buffered powder) twice daily. Patient weight > 60kg: (Tablets): 200mg orally twice daily or 400mg orally once daily. (Buffered Powder): 250mg orally twice daily.

Supplied: chewable tablet: (25, 50, 100, 150, and 200mg); Oral powder for solution (100, 167, and 200mg packets).

Renal Dosing:

Patients > 60 kg
	Tablets	Powder
30-59	100 bid or 200mg qd	100 mg bid
10-29	150mg qd	167mg qd
<10	100mg qd	100mg qd
Patients < 60kg
	Tablets	Powder
30-59	75mg bid or 150mg qd	100mg bid
10-29	100 mg qd	100 mg qd
<10	75 mg qd	100mg qd

emtricitabine (Emtriva ®)

Dosing (Adults): 200 mg orally once daily

Renal Dosing:
crcl 30-49 ml/min: 200 mg every 48 hours.
crcl 15-29 ml/min: 200 mg every 72 hours.
crcl <15 ml/min: 200 mg every 96 hours.

Supplied: Capsule: 200 mg

Epzicom ® (abacavir 600mg + lamivudine 300mg):

Dosing (Adults): One tablet (abacavir 600 mg and lamivudine 300 mg) once daily.

Renal Dosing: crcl <50 ml/min: Use not recommended.
Hepatic Impairment: Use not recommended.

Supplied: Tablet: Abacavir 600 mg & lamivudine 300 mg

lamivudine (Epivir ®)

Dosing (Adults): 150 mg orally twice daily.

Supplied: [150mg tablet; 10 mg/ml oral solution]. Lamivudine should not be co-administered with zalcitabine.

Renal Dosing: crcl >50/ no change; 30-49/ 150mg once daily; 15-29/ 150mg x1, then 100mg once daily; 5-14/ 150mg x 1, then 50 mg once daily; <5/ 50mg x1, then 25mg once daily.

stavudine (Zerit ® )

Dosing (Adults): Patient weight >60 kg: 40mg orally twice daily . Patient weight < 60kg: 30mg orally twice daily. Dosages may be decreased by 50% if peripheral neuropathy occurs. May be taken without regard to meals. Must decrease dose in renal dysfunction. Stavudine and Zidovudine should not be co-administered.

Supplied: [15, 20, 30, 40mg capsules; 1 mg/ml oral powder for solution].

Renal Dosing:

CRCL (ml/min)	WT > 60kg	WT <60kg
> 50	40mg q12h	30mg q12h
26-50	20mg q12h	15mg q12h
10-25	20mg q24h	15mg q24

tenofovir (Viread ®)

Dosing (Adults): 300 mg orally once daily with a meal.

Renal Dosing:
crcl 30-49 ml/min: 300 mg every 48 hours
crcl 10-29 ml/min: 300 mg twice weekly
crcl <10 ml/min: No recommendation available.
Hemodialysis: 300 mg every 7 days or after a total of 12 hours of dialysis (usually once weekly assuming 3 dialysis sessions lasting about 4 hours each).

Supplied: Tablet: 300 mg

Trizivir ® (abacavir 300mg + lamivudine 150mg + zidovudine 300mg)

Dosing (Adults): (>40 kg): 1 tablet orally twice daily.

Truvada ® (emtricitabine 200mg + tenofovir 300mg):

Dosing (Adults): One tablet (emtricitabine 200 mg and tenofovir 300 mg) once daily.

Renal Dosing:
crcl 30-49 ml/min: 1 tab every 48 hours
crcl <30 ml/min: Not recommended.

Supplied:Tablet: Emtricitabine 200 mg and tenofovir 300mg.

zalcitabine (Hivid ® )

Dosing (Adults): 0.75 mg orally three times daily. Lamivudine should not be co-administered with zalcitabine.

Renal Dosing: >40/ no change; 10-40/ 0.75 mg twice daily; <10/ 0.75 mg once daily. Supplied: [0.375mg , 0.75mg tablet]

zidovudine (Retrovir ® )

Dosing (Adults): 300mg orally twice daily or 200mg orally three times daily or 100mg every 4 hours 5 times daily. Stavudine and Zidovudine should not be co-administered.

Supplied: 100mg capsule; 300mg tablet; 50mg/5ml oral solution.

Renal Dosing:
Dosing in renal failure (<10 ml/min): 100mg every 6 to 8 hours. GI intolerance is common and may improve if given with meals or more frequent smaller doses. Also may cause headaches and asthenia. Main side effects are anemia and neutropenia.

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc.

Disclaimer Contact Us Privacy Policy Website Search	We comply with the HONcode standard for health trustworthy information: Verify here. Copyright © 2007 GlobalRPh Inc.