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Non-Nucleoside Reverse Transcriptase Inhibitors
HIV-Related Drug Classes Navigation |
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delavirdine (Rescriptor ®)
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Mechanism of Action Delavirdine binds directly to reverse transcriptase, blocking RNA-dependent and DNA-dependent DNA polymerase activities Dosing (Adult): Oral: 400 mg 3 times/day Administration Patients with achlorhydria should take the drug with an acidic beverage; antacids and delavirdine should be separated by 1 hour Supplied: 100, 200mg tablets. Warn of rash. |
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efavirenz (Sustiva ® )
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Mechanism of Action As a non-nucleoside reverse transcriptase inhibitor, efavirenz has activity against HIV-1 by binding to reverse transcriptase. It consequently blocks the RNA-dependent and DNA-dependent DNA polymerase activities including HIV-1 replication. It does not require intracellular phosphorylation for antiviral activity. Warn of CNS toxicity that is usually self-limited to the first three weeks of treatment. May need to avoid driving or work during this period. Dosing (Adult): > 40kg: 600 mg orally at bedtime. Administer on an empty stomach. Supplied: Capsule: 50 mg, 100 mg, 200 mg Tablet: 600 mg |
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nevirapine (Viramune ®)
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Dosing (Adult): Initially, 200mg
orally once a day for 14 days, then 200mg orally twice daily (may reduce
risk of rash). Supplied: [200mg tablet; 50mg/5 ml oral suspension]. Warn of hepatotoxicity with need to monitor liver function tests, especially during the first 12 weeks. |
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Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
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