Non-Nucleoside Reverse Transcriptase Inhibitors

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delavirdine (Rescriptor ®)

Dosing (Adult): 400mg orally three times daily.

Supplied: 100, 200mg tablets. Warn of rash.

efavirenz (Sustiva ® )

Dosing (Adult): > 40kg: 600 mg orally at bedtime.

Supplied: [50,100,200mg capsule]. Warn of CNS toxicity that is usually self-limited to the first three weeks of treatment. May need to avoid driving or work during this period.

nevirapine (Viramune ®)

Dosing (Adult): Initially, 200mg orally once a day for 14 days, then 200mg orally twice daily (may reduce risk of rash).

Supplied: [200mg tablet; 50mg/5 ml oral suspension]. Warn of hepatotoxicity with need to monitor liver function tests, especially during the first 12 weeks.

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David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.