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Metabolic Effects Significantly Lower With INVEGA(R) Compared To Olanzapine New data from a 6-month open label randomised controlled trial show INVEGA® (paliperidone ER) is associated with significantly less metabolic effects compared to oral olanzapine in people with schizophrenia, while demonstrating comparable efficacy.1 The results were presented at the 15th Biennial Winter Workshop in Psychoses in Barcelona, Spain. ...more	20 Nov 2009
Otsuka Pharmaceutical Europe Ltd Withdraws Its Application For An Extension Of Indication For Abilify (aripiprazole), Europe The European Medicines Agency has been formally notified by Otsuka Pharmaceutical Europe Ltd of its decision to withdraw its application for an extension of indication for the centrally authorised medicine Abilify (aripiprazole) tablets, orodispersible tablets and oral solution. Abilify was expected to be used in the treatment of major depressive episodes, as adjunctive therapy, in patients who have had an inadequate response to previous treatment with antidepressants. ...more	20 Nov 2009
Immune System Activated In Schizophrenia Researchers at the Swedish medical university Karolinska Institutet have discovered that patients with recent-onset schizophrenia have higher levels of inflammatory substances in their brains. Their findings offer hope of being able to treat schizophrenia with drugs that affect the immune system. The causes of schizophrenia are largely unknown, and this hinders the development of effective treatments. ...more	19 Nov 2009
Major Schizophrenia Study Finds Striking Similarities Across 37 Countries In Six Regions An international study of more than 17,000 people with schizophrenia has found striking similarities in symptoms, medication, employment and sexual problems, despite the fact that it covered a diverse range of patients and healthcare systems in 37 different countries. ...more	16 Nov 2009
Study Links Evolution Of Single Gene To Human Capacity For Language If humans are genetically related to chimps, why did our brains develop the innate ability for language and speech while theirs did not? Scientists suspect that part of the answer to the mystery lies in a gene called FOXP2. When mutated, FOXP2 can disrupt speech and language in humans. Now, a UCLA/Emory study reveals major differences between how the human and chimp versions of FOXP2 work, perhaps explaining why language is unique to humans. Published Nov. ...more	12 Nov 2009
World's Leading Experts In Schizophrenia To Meet At 26th Annual Pittsburgh Schizophrenia Conference Nov. 13 Internationally renowned experts in schizophrenia and other psychotic disorders, researchers and clinicians, patients and their families and friends will gather in Pittsburgh to discuss the latest in research and clinical advances at the 26th Annual Pittsburgh Schizophrenia Conference to be held Friday, Nov. 13, at the Sheraton Station Square, Pittsburgh. ...more	10 Nov 2009
Molecular Imaging Pinpoints Inflammation In The Brains Of Schizophrenics And Migraine Sufferers Inflammatory response of brain cells - as indicated by a molecular imaging technique - could tell researchers more about why certain neurologic disorders, such as migraine headaches and psychosis in schizophrenic patients, occur and provide insight into how to best treat them, according to two studies published in the November issue of The Journal of Nuclear Medicine. ...more	02 Nov 2009
Forest Laboratories, Inc. And Gedeon Richter Announce Positive Results From A Phase IIb Study Of Cariprazine For The Treatment Of Schizophrenia Forest Laboratories, Inc. (NYSE: FRX) and Gedeon Richter Plc announced positive top-line results from a Phase IIb clinical trial of the novel, investigational antipsychotic agent cariprazine for the treatment of acute exacerbation of schizophrenia. ...more	29 Oct 2009
Penn Researchers Reverse The Cognitive Impairment Caused By Sleep Deprivation A research collaboration led by biologists and neuroscientists at the University of Pennsylvania has found a molecular pathway in the brain that is the cause of cognitive impairment due to sleep deprivation. Just as important, the team believes that the cognitive deficits caused by sleep deprivation, such as an inability to focus, learn or memorize, may be reversible by reducing the concentration of a specific enzyme that builds up in the hippocampus of the brain. ...more	28 Oct 2009
Onset Of Schizophrenia Triggered By Faulty 'Wiring' In The Brain A new study by researchers at the Institute of Psychiatry (IoP), King's College London has discovered abnormalities in the white matter of the brain that seem to be critical for the timing of schizophrenia. The study, led by Professor Phillip McGuire and Dr Sophia Frangou, has been published in this month's edition of the British Journal of Psychiatry. The white matter of the brain consists of nerve fibres that connect parts of the brain and help regulate behaviour. ...more	27 Oct 2009
New "Schizophrenia Gene" Prompts Researchers To Test Potential Drug Target Johns Hopkins scientists report having used a commercially available drug to successfully "rescue" animal brain cells that they had intentionally damaged by manipulating a newly discovered gene that links susceptibility genes for schizophrenia and autism. The rescue, described as "surprisingly complete" by the researchers, was accomplished with rapamycin, a drug known to act on a protein called mTOR whose role involves the production of other proteins. ...more	27 Oct 2009
Rare Mutation Linked To Autism Now Also Linked To Schizophrenia Risk An international team of researchers led by geneticist Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL), has identified a mutation on human chromosome 16 that substantially increases risk for schizophrenia. The mutation in question is what scientists call a copy number variant (CNV). CNVs are areas of the genome where the number of copies of genes differs between individuals. The CNV is located in a region referred to by scientists as 16p11.2. ...more	26 Oct 2009
Minimal Relationship Between Cannabis And Schizophrenia Or Psychosis Suggested By New UK Study Last year the UK government reclassified cannabis from a class C to a class B drug, partly out of concerns that cannabis, especially the more potent varieties, may increase the risk of schizophrenia in young people. But the evidence for the relationship between cannabis and schizophrenia or psychosis remains controversial. A new study has determined that it may be necessary to stop thousands of cannabis users in order to prevent a single case of schizophrenia. ...more	24 Oct 2009
$2.1 Million Grant Awarded For Genetic Study Of Schizophrenia To US And Hebrew University Researchers The US National Institutes of Health (NIH) has awarded a $2.1 million "Grand Opportunity" (GO) grant to a team of researchers - led by Prof. Todd Lencz at the Feinstein Institute for Medical Research, New York, and Prof.Ariel Darvasi of the Silberman Institute of Life Sciences at the Hebrew University of Jerusalem - to conduct a study on the genetic basis of schizophrenia.. The team, which also includes Drs. Anil Malhotra and Peter Gregersen of the Feinstein Institute and Dr. ...more	23 Oct 2009
Epilepsy Treatment Is A Possible Culprit For Development Of Schizophrenia Researchers say antiepilectic drug treatments administered when the brain is developing appear to trigger schizophrenia-like behavior in animal models. In humans, having a history of seizures in infancy is a significant risk factor for development of schizophrenia later in life, but it is not known whether the elevated risk is due to seizures themselves, or from side effects antiepileptic drug (AED) treatment. ...more	21 Oct 2009
Scientists Demonstrate Link Between Genetic Defect And Brain Changes In Schizophrenia For decades, scientists have thought the faulty neural wiring that predisposes individuals to behavioral disorders like autism and psychiatric diseases like schizophrenia must occur during development. Even so, no one has ever shown that a risk gene for the disease actually disrupts brain development. ...more	17 Oct 2009
Clinical And Regulatory Aspects Of Trials With Negative Symptoms Of Schizophrenia Discussed At ISCTM Meeting A half-day workshop on issues in the design of clinical trials to evaluate treatments for negative symptoms of schizophrenia, chaired by Stephen Marder, MD, UCLA Department of Psychiatry and David Daniel, M.D., United BioSource Corporation was held 5 October 2009, as part of the International Society for CNS Clinical Trials and Methodology (ISCTM) Autumn Conference in San Diego, CA. ...more	16 Oct 2009
Diagnosing Depression In An Hour Using 'ECG For The Mind' An innovative diagnostic technique invented by a Monash University researcher could dramatically fast-track the detection of mental and neurological illnesses. Monash biomedical engineer Brian Lithgow has developed electrovestibulography which is something akin to an 'ECG for the mind'. ...more	16 Oct 2009
Case Western Reserve University Researchers Receive $1.25 Million From National Institutes Of Mental Health To Study Schizophrenia Case Western Reserve University School of Medicine has received $1.25 million from the National Institutes of Mental Health, part of the National Institutes of Health, to study schizophrenia from an interdisciplinary standpoint. The grant, to be funded over four years, includes three project investigators from three different practice areas. ...more	15 Oct 2009
Fear Of Mentally Ill Is Misplaced: Stranger Homicide By People With Schizophrenia Is Rare And Unpredictable International study led by Sydney researchers shows homicides of strangers by people with schizophrenia are exceptionally rare and unpredictable events A study initiated by a team of Sydney researchers published in the leading schizophrenia journal, Schizophrenia Bulletin, shows that homicides of strangers by people diagnosed with schizophrenia are exceptionally rare events. ...more	13 Oct 2009
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