Methadone And Other Opioids Not Always Equivalent, Conversion Can Be Lethal
In a unique and comprehensive literature review of poisoning deaths involving opioids from 1999 -- 2009, the deaths involving methadone were found to be disproportionately high. Methadone represented less than five percent of all opioid prescriptions but is responsible for a third of the deaths... ...more
Researchers Identify Racial Differences In Pain Treatment Outcomes
Findings from a retrospective analysis of a three-week treatment program for chronic pain revealed African Americans experienced worse outcomes compared to a matched group of Caucasians. The research was presented at the American Academy of Pain Medicine's 26th Annual Meeting in San Antonio... ...more
05 Feb 2010
King Launches PainBalance®: Educational Initiative To Help Reduce The Burden Of Pain
King Pharmaceuticals®, Inc. launched PainBalance®, a new educational initiative which provides quality information, practical tools, and essential resources to healthcare professionals and others, helping them provide optimal, appropriate care for all patients with pain... ...more
Stopping Pain Without Affecting Motor Function
One of the holy grails of local anesthesia is the ability to achieve a long-lasting nerve block that eliminates pain sensation while not affecting motor function. Now, researchers at Children's Hospital Boston have discovered an anesthetic approach that seems to do just that... ...more
03 Feb 2010
Decreased Muscle Strength Predicts Functional Impairments In Older Adults
Decreased muscle strength is associated with difficulty in performing functional activities such as stooping, crouching, or kneeling (SCK) in older adults, according to an observational study published in the January issue of Physical Therapy, (PTJ) the scientific journal of the American Physical Therapy Association (APTA)... ...more
03 Feb 2010
New Nanoscopic Material Enables Cartilage To Do What It Doesn't Do Naturally
Northwestern University researchers are the first to design a bioactive nanomaterial that promotes the growth of new cartilage in vivo and without the use of expensive growth factors. Minimally invasive, the therapy activates the bone marrow stem cells and produces natural cartilage. No conventional therapy can do this. The results will be published online the week of Feb... ...more
02 Feb 2010
Acetaminophen Protects Kidneys After Muscle Injury
Severe muscle injuries - such as crush injuries suffered in earthquakes, car accidents and explosions, and muscle damage from excessive exercise or statin drug interactions - can cause life-threatening kidney damage. Treatment has been limited to intravenous fluids and dialysis, but a new study suggests that the commonly used pain reliever acetaminophen may protect the kidneys from damage... ...more
02 Feb 2010
Immune Protein Fends Off Exotic Virus
A study published online on February 1 in the Journal of Experimental Medicine shows that antiviral proteins called type I interferons (IFNs) are needed to fend off infection with an exotic mosquito-borne virus called Chikungunya virus... ...more
02 Feb 2010
New Treatment For Chronic Pain Condition
Scientists at the University of Liverpool have discovered that treating the immune system of patients with Complex Regional Pain Syndrome (CPRS) leads to a significant reduction in pain. CRPS is an unexplained chronic pain condition that usually develops after an injury or trauma to a limb, and continues after the injury has healed... ...more
02 Feb 2010
FDA Cautions Drug Makers About Potential Abuse
The Los Angeles Times reports that the Food and Drug Administration "this week released a draft of voluntary guidelines to assist drug makers in figuring out which compounds should be placed under the Controlled Substances Act... ...more
29 Jan 2010
Brain Responses During Anesthesia Mimic Those During Natural Deep Sleep
The brains of people under anesthesia respond to stimuli as they do in the deepest part of sleep - lending credence to a developing theory of consciousness and suggesting a new method to assess loss of consciousness in conditions such as coma... ...more
The Brain's Developing Pain Regulatory System Can Be Altered By Prenatal Alcohol Exposure
Prenatal alcohol exposure is widely known to impair brain development in exposed offspring. Rodent studies have shown that developmental deficits in newborns related to altered levels of a brain chemical called serotonin (5-HT), leading to subsequent alterations in patterns of neonatal acute pain responses and/or hypothalamic-pituitary-adrenal (HPA) stress reactivity... ...more
28 Jan 2010
FDA Approves Morphine Sulfate Oral Solution For Relief Of Acute And Chronic Pain
The U.S. Food and Drug Administration today approved Morphine Sulfate Oral Solution for the relief of moderate to severe, acute and chronic pain in opioid-tolerant patients. This medicine will be available in 100 milligrams per 5 mL or 20 milligrams per 1 mL. This is the only FDA approved morphine sulfate oral solution available at this concentration... ...more