New Chemical May Play Key Role In Hospital Superbugs' Battle, UK
A new chemical compound that mimics the body's ability to fight bacteria could help target hospital-acquired infections such as MRSA and C.difficile. The compound, which could be added to detergents or used as a coating for hospital equipment, is able to trap and release the gas nitric oxide - which is also produced by our own immune systems to kill bugs. ...more
20 Nov 2009
Recent Developments At Burnham Institute For Medical Research, November 2009
New antibiotics for methicillin-resistant Staphylococcus aureus (MRSA) and other pesky bacteria. Andrei Osterman and collaborators have used comparisons of bacterial genomes to identify new targets for antibiotics and produced first-generation chemical inhibitors of a class of bacterial enzymes, called NadDs (nicotinate mononucleotide adenylyltransferases). Described in a recent article in Chemistry & Biology (Cell Press), the team, led by Dr. ...more
18 Nov 2009
Why Certain Drug Combinations Backfire
Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow. Just as some drugs work better together, however, other pairings are counter-productive. ...more
16 Nov 2009
To Avoid Spreading Germs, Expert Recommends Hand Washing
Fears of contracting the H1N1 virus this flu season have people steering clear of strangers with coughs and scolding friends who don't sneeze into their crooked elbows. With everyone trying to stay germ free, hand sanitizer has become a popular means of protection. But although a quick pump from a Purell dispenser is the most convenient form of hand cleaning, is it the best? Not necessarily, according to Saint Joseph's University medical microbiology expert Michael McCann, Ph.D. ...more
11 Nov 2009
New Three-Year Grant From The Bill & Melinda Gates Foundation Announced By Keystone Symposia
Keystone Symposia on Molecular and Cellular Biology is pleased to announce that it has received a second grant from the Bill & Melinda Gates Foundation to fund conferences on infectious disease in its "Keystone Symposia Global Health Series." In 2006, the Colorado, USA-based nonprofit organization received its first three-year grant; the funding for that ended with the October 20-25, 2009 conference on "Overcoming the Crisis of TB and AIDS" in Arusha, Tanzania. The new grant provides $2. ...more
10 Nov 2009
Creation Of New Transatlantic Task Force On Global Antibiotic Resistance Threat Applauded By U.S. And European Experts
Experts on both sides of the Atlantic applaud President Barack Obama and Swedish Prime Minister Fredrik Reinfeldt, representing the European Union (EU) Presidency, for establishing a transatlantic task force to address antibiotic resistance, an urgent and growing problem that threatens patient safety and public health worldwide. During a summit held this week in Washington, D.C. ...more
10 Nov 2009
'Clever Cleaning' The Way To Beat Hospital Superbugs, UK
Just one extra cleaner on a hospital ward can save lives and money, according to new research sponsored by UNISON, the UK's largest public service union. The detailed study found that one extra cleaner, using targeted cleaning methods, had a "measurable effect on the clinical environment," cutting the number of patients who contracted MRSA and saving the hospital an estimated £30,000 - £70,000. ...more
10 Nov 2009
Silver (And Copper) Antimicrobial Bullets To Kill Bacteria
Dana Filoti of the University of New Hampshire will present thin films of silver and copper she has developed that can kill bacteria and may one day help to cut down on hospital infections. The antimicrobial properties of silver and copper have been known for centuries -- last year, the U.S. Environmental Protection Agency officially registered copper alloys, allowing them to be marketed with the label "kills 99.9% of bacteria within two hours. ...more
10 Nov 2009
Bacteria 'Launch A Shield' To Resist Attack
Researchers from the University of Copenhagen and the Technical University of Denmark along with other collaborators in Denmark and the US found that the bacterium Pseudomonas aeruginosa can 'switch on' production of molecules that kill white blood cells - preventing the bacteria being eliminated by the body's immune system. P. ...more
03 Nov 2009
MRSA Strain Linked To High Death Rates
A strain of MRSA that causes bloodstream infections is five times more lethal than other strains and has shown to have some resistance to the potent antibiotic drug vancomycin used to treat MRSA, according to a Henry Ford Hospital study. The study found that 50 percent of the patients infected with the strain died within 30 days compared to 11 percent of patients infected with other MRSA strains. ...more
02 Nov 2009
Winner Of First Healthcare Administrator Award Announced By APIC
Deborah Friberg, Chief Operating Officer and Executive Vice President of WakeMed Health and Hospitals, Raleigh, North Carolina, has been named the recipient of the first annual Healthcare Administrator Award, presented by the Association for Professionals in Infection Control and Epidemiology (APIC). The award recognizes a healthcare facility's executive team member who has demonstrated significant support for infection prevention and control throughout their facility. ...more
22 Oct 2009
Swine Flu Return May Cause Rise In MRSA, Warns Influential Expert Group
As NHS hospitals face an even tougher winter than usual managing the rise in demand for beds alongside the second wave of swine flu, an influential group of doctors, scientists and patient representatives has called for the early discharge of appropriate MRSA patients to prevent a rise in MRSA infection rates. ...more
22 Oct 2009
Metals Could Forge New Cancer Drug
Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds. ...more
Misuse Of Antibiotics Not The Only Cause Of Resistance
The perception that antibiotic resistance is primarily the undesirable consequence of antibiotic abuse or misuse is a view that is simplistic and inaccurate, according to a recent report by the American Academy of Microbiology. The reasons behind the spread of resistance are much more complex, including appropriate antibiotic use, lack of proper sanitation and hygiene, and even the environment. ...more
17 Oct 2009
NanoBio's Nanoemulsion Kills Drug-Resistant Bacteria Found In Cystic Fibrosis Patients
NanoBio Corporation today announced compelling preclinical data for NB-401, a nebulized nanoemulsion-based agent that kills highly drug-resistant strains of bacteria commonly found in cystic fibrosis patients. Currently there are limited treatment options available that effectively address these resistant bacteria. The study results are being presented today at the 2009 Annual North American Cystic Fibrosis Conference (NACFC) in Minneapolis, Minn. ...more
17 Oct 2009
News Outlets Examine Efforts To Control TB In South Africa
Agence France-Presse examines the ongoing fight to control the spread of tuberculosis in South Africa. "The World Health Organisation estimates almost one percent or 461,000 South Africans develop TB annually, with government figures showing that the disease was the country's leading natural cause of death in 2006," the news service writes. ...more
16 Oct 2009
Candidates For New HIV Drugs Found By Pitt Researchers
While studying an HIV protein that plays an essential role in AIDS progression, researchers at the University of Pittsburgh School of Medicine have discovered compounds that show promise as novel treatments for the disease. HIV drug discovery efforts have met with little success in finding compounds that interact with an important HIV virulence factor, called Nef, because it lacks biochemical activity that can be directly measured, explained Thomas E. Smithgall, Ph.D., William S. ...more
Researchers Present 'a Novel, Automated, Efficient Environmental Disinfection Technology That Significantly Reduces C. Difficile, VRE And MRSA
In a study presented at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), researchers used a mobile, automated UV device to decontaminate hospital rooms at the Cleveland Veterans Affairs (VA) Medical Center in Ohio and analyzed its ability to remove troublesome bacteria, including C. difficile spores. The device, known as Tru-D, uses reflected UVC germicidal energy to decontaminate air and surfaces, including those in primary shadows. ...more