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Immune System/Vaccines News
Linkage Biosciences Unveils LinkSeqTM -- A Revolutionary New Tool For Immunogenetic Testing
Linkage Biosciences, Inc., a privately held molecular diagnostics company, recently unveiled LinkSeq™ -- a new one-step method for Human Leukocyte Antigen (HLA) testing -- at the annual meeting of the American Society of Histocompatibility and Immunogenetics (ASHI) in San Francisco. Much faster than other HLA testing methods currently available, LinkSeq™ is a proprietary sequence-specific priming (SSP) chemistry that can be analyzed utilizing real-time PCR platforms. ...more		 20 Nov 2009
Yale Researchers Target Tick Saliva In Their Search For Lyme Disease
A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites. Traditionally, vaccines have directly targeted specific pathogens. ...more		 20 Nov 2009
Asthma A Significant Risk Factor For Complications In Children With H1N1
A new study on pediatric H1N1 influenza admissions has found that asthma is a significant risk factor for severe disease in children with pandemic H1N1 compared with the seasonal flu. The study (http://www.cmaj.ca/cgi/rapidpdf/cmaj.091724), led by researchers from The Hospital for Sick Children (SickKids) in Toronto, Ontario, is published online in CMAJ (Canadian Medical Association Journal). ...more		 20 Nov 2009
Potential Strategy To Help Generate HIV-Neutralizing Antibodies
WHAT: New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. ...more		 20 Nov 2009
Military Study Shows Prevention Of Novel A/H1N1 Virus Infection Is Vaccine-Type And Age-Dependent
Immunization with either live attenuated influenza vaccine (LAIV, also known as FluMist®), or trivalent inactivated influenza vaccine (TIV), appears to offer a protection (~ 45%) against the novel A/H1N1 virus, the cause of the present influenza pandemic. However, the benefit was largely attributed to the youngest age group. The finding emerges from an evaluation of medical encounters and seasonal influenza immunization of U.S. military service members. ...more		 20 Nov 2009
AFFiRiS AG: Interim Analysis Of Clinical Phase I Data Triggered Decision To Move Alzheimer's Vaccine Candidate AD02 Into Clinical Phase II Testing
AFFiRiS AG will focus its Alzheimer's vaccine program on one product candidate at an unexpectedly early stage of development: the vaccine candidate AD02 is planned to enter into Phase II clinical trial early in 2010. This decision by the company immediately follows the completion of two Phase I trials with the candidates AD01 and AD02. The company based its fast decision on the first interim analysis of the secondary endpoints at the six month time point. ...more		 20 Nov 2009
Inovio Biomedical Universal DNA Vaccine For Chikungunya Virus Demonstrates Protective Antibody Responses In Monkey Model
Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that the company's SynCon™ Chikungunya virus DNA vaccine induced protective neutralizing antibody responses in a preclinical non-human primate model. Dr. David B. ...more		 20 Nov 2009
Immunologist At Children's Hospital Receives Daland Prize For Patient-Oriented Research
A pediatric immunologist at The Children's Hospital of Philadelphia has received a prestigious annual award from the American Philosophical Society, an organization founded in 1743 by Benjamin Franklin. Jordan S. Orange, M.D., Ph.D., received the Society's Judson Daland Prize on Nov. 13 for his contributions to research and treatment of inherited immune deficiency diseases. ...more		 20 Nov 2009
FDA Advisory Committee Finds Data Support The Safety And Effectiveness Of Prevnar 13™ Vaccine For The Prevention Of Invasive Pneumococcal Diseas
Pfizer Inc (NYSE:PFE) announced today that the U.S. Food and Drug Administration's (FDA) Vaccines and Related Biological Products Advisory Committee voted 10 to 1 that the data presented support the safety and effectiveness of its 13-valent pneumococcal conjugate candidate vaccine, Prevnar 13™ (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), for the prevention of invasive pneumococcal disease in infants and young children. ...more		 20 Nov 2009
Also In Global Health News: Sleeping Sickness; Aid For Philippines; U.S., China In Africa; Polio Eradication In Afghanistan; Ethiopia Famine
Lancet Infectious Diseases Examines Hold-Ups In Implementation Of Sleeping Sickness Therapy ...more		 19 Nov 2009
WHO To Launch Yellow Fever Vaccination Campaign In West Africa
The WHO on Tuesday announced it would lead a week-long, multi-country vaccination campaign in Africa next week to protect those "deemed at highest risk from yellow fever," Reuters reports. The vaccination drive will target nearly 12 million Africans living in Benin, Liberia and Sierra Leone - all countries at high risk of yellow fever outbreaks (Nebehay/MacInnis, 11/17). ...more		 19 Nov 2009
An Overactive Immune Response Linked To Viral Infections Among Elderly
Researchers at Yale School of Medicine have found that exaggerated responses of the immune system explain why the elderly succumb to viral infections more readily than younger people. Published in the November 19 Cell Host & Microbe, the study bucks the general belief that declining immune responses are to blame for susceptibility to viral infections. ...more		 19 Nov 2009
Women At Risk From Vitamin A Deficiency
Almost half of UK women could be suffering from a lack of vitamin A due to a previously undiscovered genetic variation, scientists at Newcastle University have found. The team, led by Dr Georg Lietz, has shown that almost 50 per cent of women have a genetic variation which reduces their ability to produce sufficient amounts of vitamin A from beta-carotene. ...more		 19 Nov 2009
GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data Shows
The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. ...more		 19 Nov 2009
U.S. Health Officials Testify Before Senate Committee About H1N1 Vaccine Campaign
U.S. health officials defended their handling of the country's H1N1 (swine flu) vaccine campaign Tuesday "against criticism that their plan to protect Americans was confusing and over-optimistic," Reuters reports (Fox, 11/17). ...more		 19 Nov 2009
Have Egg Allergy? You May Still Be Candidate For Flu Vaccines, Says Allergist
As flu season got underway this fall, Dr. Catherine Monteleone, an allergist, noticed that her office started to receive an unusually high number of calls from people with egg allergy. They previously had avoided flu vaccines because of their sensitivity to eggs. This year, with all the attention being paid to the novel H1N1 influenza, those patients want to be protected against flu, and they contacted her to find out if they are candidates for inoculation. ...more		 19 Nov 2009
Immune System Activated In Schizophrenia
Researchers at the Swedish medical university Karolinska Institutet have discovered that patients with recent-onset schizophrenia have higher levels of inflammatory substances in their brains. Their findings offer hope of being able to treat schizophrenia with drugs that affect the immune system. The causes of schizophrenia are largely unknown, and this hinders the development of effective treatments. ...more		 19 Nov 2009
Researchers Discover Antibody Receptor Identity, Propose Renaming Immune-System Gene
Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders. The discovery is such a crucial part of immunology that UAB researchers, in conjunction with Japanese researchers, are asking that the gene linked to this antibody receptor be renamed to better describe its role in early immune responses. ...more		 19 Nov 2009
Immune Cells On The Move
Scientists from the Max Planck Institute (MPI) of Biochemistry in Martinsried near Munich, Germany, have now deciphered the mechanism that illustrates how these mobile cells move on diverse surfaces. "Similar to a car, these cells have an engine, a clutch and wheels which provide the necessary friction," explains Michael Sixt, a research group leader at the MPI of Biochemistry. ...more		 19 Nov 2009
KHN Column: Is Fear Of Flu Shifting The Goal Posts?
In this column for Kaiser Health News, Shannon Brownlee and Jeanne Lenzer write about the swine flu. "If any public health message has alarmed Americans in recent weeks, it is the repeated claim in the media that healthy young people are dying of 2009 H1N1, or swine flu. ... ...more		 18 Nov 2009
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