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Pitt Researcher To Co-Direct National Consortium On Facial Birth Defects Researchers at the University of Pittsburgh and the University of Iowa will lead a $9 million, five-year initiative to study the cause of facial birth defects. The FaceBase Consortium will create an encyclopedic database of how the faces of children develop and what goes wrong to cause malformations. FaceBase will build a list of the genes and proteins that drive embryonic cell differentiation around the forming mouth. ...more	18 Nov 2009
Progress Report On Cleft Palate Surgery In Developing Countries Craniofacial surgeons around the world are striving toward a critical goal: making high-quality cleft palate and craniofacial reconstructive surgical services available to children in developing countries. ...more	25 Oct 2009
FaceBase Consortium Launched By NIDCR Although about half of all birth defects involve the face and skull, scientists remain unclear about why most occur. To help families at risk for these conditions, what's needed is a comprehensive and systematic understanding of how the faces of healthy children develop and what goes awry to cause common malformations. With today's improved technologies, researchers can generate megabytes of information in a single experiment on hundreds of genes that are involved in the process. ...more	08 Oct 2009
Titan Announces Award Of NIH Grant For Probuphine(R) Clinical Development Titan Pharmaceuticals, Inc (Pink Sheets:TTNP) announced that the National Institutes of Health (NIH) has awarded a Research and Research Infrastructure Grand Opportunities grant to the company through the American Reinvestment and Recovery Act of 2009 (ARRA). The two year grant for Probuphine clinical development is expected to provide approximately $7.6 million, with the first year award of approximately $ 5.6 million now made available to Titan by the NIH. ...more	04 Oct 2009
PCE Exposure Increases Risk Of Birth Defects Exposure to tetrachloroethylene (also known as perchlorethylene, PCE) may cause congenital birth defects. A study of expectant women exposed to PCE in drinking water, published in BioMed Central's open access journal Environmental Health, found an increased risk of oral clefts and neural tube defects in their children. ...more	24 Sept 2009
PSivida Corp Reports Favorable 12-Month Interim Safety And Efficacy Results From Iluvien™ Human PK Study pSivida Corp. (NASDAQ:PSDV)(ASX:PVA)(FF:PV3), a leading drug delivery company, reported the interim 12-month safety and efficacy results from the first human pharmacokinetic study (PK Study) of Iluvien™. The study is being conducted by the Company's licensing partner Alimera Sciences. Iluvien is an intravitreal insert being developed for the treatment of diabetic macular edema (DME). ...more	16 Mar 2009
Bonn Scientists Discover Gene Locus Associated With Cleft Lip And Palate Comparing 500,000 snippets of human DNA put scientists from the University of Bonn on the right track. A genetic variant on chromosome 8 occurs with significantly higher frequency in people with cleft lip and palate than in the control group. The results are to be published in the forthcoming issue of the journal Nature Genetics. Cleft lips and palates are among the most frequent innate abnormalities. One in about 700 babies in Central Europe are affected. ...more	09 Mar 2009
Increased Prevalence Of Left-Handedness In Children With Facial Development Disorder A new study by physician researchers from Hasbro Children's Hospital and Children's Hospital Boston has identified an increased prevalence in left-handedness in children with a congenital disorder known as hemifacial microsomia (HFM). The study was published in the March 2009 edition of the Journal of Craniofacial Surgery. Overall, ten percent of the population is left-handed. ...more	04 Mar 2009
Scientists Discover Why Teeth Form In A Single Row And How Each Tooth Signals The Next To Start Growing A system of opposing genetic forces determines why mammals develop a single row of teeth, while sharks sport several, according to a study published today in the journal Science. When completely understood, the genetic program described in the study may help guide efforts to re-grow missing teeth and prevent cleft palate, one of the most common birth defects. ...more	28 Feb 2009
Advancement In Tissue Engineering Promotes Oral Wound Healing Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) reconstruction has taken a significant step forward with a Netherlands-based research team's successful development of a gum tissue (gingival) substitute that can be used for reconstruction in the oral cavity. Their work was reported in the current issue of Cell Transplantation (17:10/11). According to the study's lead author, Dr. ...more	04 Feb 2009
Study Of Changes In MSX Gene Family Over 600 Million Years Leads To New Understanding Of Disease Patterns The work of Forsyth scientist Peter Jezewski, DDS, Ph.D., has revealed that duplication and diversification of protein regions ('modules') within ancient master control genes is key to the understanding of certain birth disorders. Tracing the history of these changes within the proteins coded by the Msx gene family over the past 600 million years has also provided additional evidence for the ancient origin of the human mouth. Dr. ...more	14 Jan 2009
Oral Clefts And First Trimester Smoking Linked Smoking during the first trimester of pregnancy is clearly linked with an increased risk of cleft lip in newborns. Genes that play a role in detoxification of cigarette smoke do not appear to be involved. This is shown in a new study published in the journal Epidemiology. Oral clefts are one of the most common birth defects. Closure of the lip occurs about 5 weeks into pregnancy, followed by closure of the palate at week 9. ...more	24 Dec 2008
Increased Risk Of Birth Defects Linked To Maternal Smoking Babies whose mothers smoked during pregnancy were more than twice as likely to have a cleft palate or lip as those whose mothers didn't, according to research results released today. Although the study confirms earlier findings, it is unique because it did not rely on women's self-reported smoking habits during pregnancy. Instead, researchers used the more reliable method of measuring the levels of cotinine, a metabolite of nicotine, in the blood from about 500 pregnant women. ...more	05 Nov 2008
Genetic Variant Plays Role In Cleft Lip University of Iowa researchers and collaborators have found, in a previously identified gene, a variation that likely contributes to one in five cases of isolated cleft lip. It is the first time a genetic variant has been associated with cleft lip alone, rather than both cleft lip and palate. ...more	08 Oct 2008
Susceptibility To Cleft Palate Revealed By Genetic Profile For the first time, researchers from the University of Pittsburgh School of Dental Medicine have identified a series of genetic mutations that appear to be linked to significant risk for cleft palate and other dental abnormalities. These are devastating conditions that cause tremendous social isolation, and also are associated with decreased lifespan, a higher risk of cancer and increased susceptibility to psychiatric disorders, even after surgical repair. ...more	16 Sept 2008
Alternate Pathway That Leads To Palate Development Researchers at the University Of Southern California School Of Dentistry have uncovered another clue behind the causes of cleft palate and the process that leads to palate formation. Cleft palate is one of the most common congenital birth defects, occurring in one out of every 700 live births. Clefts are more common in children of American Indian, Hispanic or Asian descent. While males are twice as likely to have a cleft lip, females are twice as likely to have a cleft palate. ...more	12 Aug 2008
Alcohol Binges Early In Pregnancy Increase Risk Of Infant Oral Clefts A new study by researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, shows that pregnant women who binge drink early in their pregnancy increase the likelihood that their babies will be born with oral clefts. ...more	01 Aug 2008
California Legislature Takes Up Multiple Health Care Bills "More than a dozen health bills are advancing through the [California] Legislature," some of which contain elements of a health care overhaul plan backed by Gov. Arnold Schwarzenegger (R) that passed the state Assembly but was rejected in the Senate earlier this year, the ...more	30 July 2008
Keynoters, Symposia, Workshops Highlight Dental Research Meeting Following is a summary of the keynote presentations, symposia, and workshops that will anchor the 37th Annual Meeting of the American Association for Dental Research, convening April 2 at the Hilton Anatole Hotel. Keynote Presentations Wednesday, April 2 * "Optimizing the Survival of Ceramic Prostheses: Lessons Learned from the Analysis of Clinical Failures", Susanne Scherrer (University of Geneva, Switzerland), 3:15 p.m. ...more	30 July 2008
Research Findings Change The Way Doctors Perform Cleft Palate Surgery Research by Dr. Damir Matic, a scientist with Lawson Health Research Institute in London, Ontario is changing the way cleft palate surgeries are performed throughout North America and around the world. Matic has been conducting research to determine the optimal time to close the gum tissue of cleft palate patients. His research suggests that it is best to wait until the child is older. ...more	13 May 2008
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