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COLD-FX(R) Maker Broadens Its Scientific Direction: Launches Pilot Trial Of New Formulation LIP-01 Geared To Lowering Cholesterol And Lipids Afexa Life Sciences Inc. ("Afexa" or the "Company") (TSX:FXA) maker of COLD-FX announced the launch of a pilot clinical trial of a new formulation, LIP-01 that has shown promise in reducing blood lipids - including cholesterol. Cholesterol can stick to the walls of arteries, causing atherosclerosis or "hardening of the arteries." This, in turn, can ultimately lead to a heart attack or stroke. ...more	20 Nov 2009
Prevalence Of High LDL, Or 'Bad' Cholesterol Levels Decreases In U.S. Between 1999 and 2006, the prevalence of adults in the U.S. with high levels of LDL cholesterol, the "bad" cholesterol, decreased by about one-third, according to a study in the November 18 issue of JAMA. But a high percentage of adults still are not being screened or treated for high cholesterol levels. ...more	20 Nov 2009
Pfizer Submits New Pediatric Data For Lipitor(R) (Atorvastatin) To The European Medicines Agency (EMEA) Pfizer Inc (NYSE:PFE) announced it has submitted pediatric data for Lipitor® (atorvastatin) to the European Medicines Agency (EMEA). Pfizer has also developed a new chewable form of Lipitor, including a pediatric-appropriate 5 mg dose, which is part of this submission. ...more	19 Nov 2009
The Protein Srebp2 Drives Cholesterol Formation In Prion-Infected Neuronal Cells Which May Promote Prion-Dependent Diseases Prions are causing fatal and infectious diseases of the nervous system, such as the mad cow disease (BSE), scrapie in sheep or Creutzfeldt-Jakob disease in humans. Scientists of Helmholtz Zentrum MÃ¼nchen and Technische UniversitÃ¤t MÃ¼nchen have now succeeded in elucidating another disease mechanism of prion diseases: The prion-infected cell changes its gene expression and produces increased quantities of cholesterol. Prions need this for their propagation. ...more	19 Nov 2009
Levels Of Bad Cholesterol Falling In US, But Still Too Many Unscreened And Untreated A new study published this week found that the proportion of American adults with high levels of low-density lipoprotein (LDL or "bad") cholesterol fell by around one third between 1999 and 2006, but concluded that too many are still not being screened or treated for the condition. ...more	19 Nov 2009
Increased Obesity Hindering Success At Reducing Heart Disease Risk The dramatic increase in overweight and obesity in adult Americans over the past 20 years has undermined public health success at reducing risk for heart disease, according to research presented at the American Heart Association's Scientific Sessions 2009. In a new study, researchers analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 1988-2006, representing 8,264 adult men and women, 20 to 85 years old. ...more	18 Nov 2009
Scans Of Egyptian Mummies Show Hardening Of Arteries Is Not A Modern Disease An international team of scientists who took CT scans of mummified bodies of people who lived in Egypt up to 3,500 years ago found evidence to suggest that hardening of arteries, a risk factor for heart attacks and strokes, is not a modern disease and may have been quite common among ancient Egyptians of high socioeconomic status. ...more	18 Nov 2009
Columbia's 2009 Naomi Berrie Award For Diabetes Research Columbia University Medical Center presentED the 2009 Naomi Berrie Awards to a nationally recognized diabetes researcher, and a promising young investigator, for their outstanding achievements in diabetes research. The Award for Outstanding Achievement in Diabetes Research WENT to Richard Nathan Bergman, Ph.D, Professor and Chair of the Department of Physiology & Biophysics at the Keck School of Medicine of the University of Southern California (USC). Dr. ...more	16 Nov 2009
New Web Sites Educate About Triglycerides And HDL Cholesterol Nearly one in three adult Americans have triglyceride (trig) levels that are above normal and nearly 34 million have low HDL "good" cholesterol levels. To help increase awareness about the importance of HDL and trigs, Abbott has launched two Web sites: http://www.knowyourhdl.com and http://www.knowyourtrigs.com. ...more	15 Nov 2009
Over-Consumption Of Selenium Can Increase Cholesterol A new study from the University of Warwick has discovered taking too much of the essential mineral selenium in your diet can increase your cholesterol by almost 10%. Selenium is a trace essential mineral with anti-oxidant properties. The body naturally absorbs selenium from foods such as vegetables, meat and seafood. However, when the balance is altered and the body absorbs too much selenium, such as through taking selenium supplements, it can have adverse affects. ...more	14 Nov 2009
UCLA Researchers Reconstitute Enzyme That Synthesizes Cholesterol Drug Lovastatin Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin. The research, published Oct. 23 in the journal Science, could potentially lead to the development of other compounds with similarly beneficial effects. ...more	05 Nov 2009
Risk For High-Grade Prostate Cancer May Be Reduced By Low Cholesterol Men with lower cholesterol are less likely than those with higher levels to develop high-grade prostate cancer - an aggressive form of the disease with a poorer prognosis, according to results of a Johns Hopkins collaborative study. In a prospective study of more than 5,000 U.S. men, epidemiologists say they now have evidence that having lower levels of heart-clogging fat may cut a man's risk of this form of cancer by nearly 60 percent. ...more	04 Nov 2009
Answers And Some New Questions Concerning Cholesterol And Cancer A pair of studies in Cancer Epidemiology, Biomarkers & Prevention, lay to rest the decades-long concern that lower total cholesterol may lead to cancer, and in fact lower cholesterol may reduce the risk of high-grade prostate cancer. Demetrius Albanes, M.D., a senior investigator at the National Cancer Institute, said early studies suggested that low cholesterol could increase the risk of certain types of cancer. ...more	04 Nov 2009
Studies Negate Concerns That Low Cholesterol Leads To Some Cancers Two new studies from the US published this week negate concerns that have been around since early studies done decades ago suggested that low cholesterol leads to some types of cancer: one in fact affirms that undiagnosed cancer is the likely cause of lower total cholesterol while the other found evidence linking low cholesterol and decreased risk of high-grade prostate cancer among older men. ...more	04 Nov 2009
Statins Show Dramatic Drug And Cell Dependent Effects In The Brain Besides their tremendous value in treating high cholesterol and lowering the risk of heart disease, statins have also been reported to potentially lower the risks of other diseases, such as dementia. However, a study in the October Journal of Lipid Research finds that similar statin drugs can have profoundly different effects on brain cells - both beneficial and detrimental. ...more	29 Oct 2009
Ezetimibe Makes Atorvastatin More Efficient In Lowering Lipids In Men And Women Age 65 And Older Adding ezetimibe to atorvastatin significantly boosted the attainment of lipid targets as specified by both Canadian and European guidelines in elderly patients aged 65 and older and the combination produced superior results than simply increasing the dose of atorvastatin alone, Dr. Christian Constance told the Canadian Cardiovascular Congress 2009, co-hosted by the Heart and Stroke Foundation and the Canadian Cardiovascular Society. ...more	29 Oct 2009
New CVD Guidelines And Position Papers Several new guidelines and position papers offering the most up to date information to ensure that clinicians practice evidence-based medicine were released at the Canadian Cardiovascular Congress 2009 this week. ...more	29 Oct 2009
Study Demonstrates LIVALO(R) Is An Efficacious Treatment For Achieving Lipid Goals New Phase III data published in "Current Medical Research and Opinion" highlight that the recommended starting dose of 2 mg of LIVALO (pitavastatin), a novel synthetic statin, was statistically superior to simvastatin at a dose of 20 mg over 12 weeks in reducing low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) and total cholesterol (TC) in patients with primary hypercholesterolemia and combined dyslipidemia. ...more	23 Oct 2009
Research Indicates Gaps In Care For Diabetes, Cholesterol, Hypertension Among The Uninsured A new study shows uninsured American adults with chronic illnesses like diabetes or high cholesterol often go undiagnosed and undertreated, leading to an increased risk of costly, disabling and even lethal complications of their disease. The study, published online in Health Affairs, analyzed data from a recent national survey conducted by the Centers for Disease Control and Prevention (CDC). ...more	21 Oct 2009
Teaming Up For Heart Disease: ASU's Biodesign Institute And Singapore's National University Health System In a new international partnership, Dr. Randy Nelson, a researcher at Arizona State University's Biodesign Institute, and Dr. Tai E-Shyong, associate professor at Singapore's National University Hospital, National University Health System (NUHS), have teamed up to assess the risk of heart disease in diabetics with greater accuracy. ...more	08 Oct 2009
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