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Nasal Preparations
azelastine (Astelin ® ) |
| Antihistamine. Allergic rhinitis: use 2 sprays in each nostril twice daily. |
beclomethasone (Vancenase ® , Beconase ®) |
| Dosing: one spray 2 to 4 times daily. |
budesonide (Rhinocort ® ) |
|
Allergic Rhinitis - Dosing: Two sprays twice daily or 4
sprays once daily. (Rhinocort Aqua Nasal Spray®): - Recommended starting dose (adults): 1 spray in each nostril once daily. Maximum recommended dose for adults (12 years of age and older): 256 mcg per day administered as four sprays per nostril once daily [Supplied: Nasal Spray- 32 mcg/spray] |
cromolyn (NasalCrom ® ) |
| Allergic rhinitis: 1 spray/nostril 3-6 times/day |
desmopressin acetate (DDAVP®) Nasal Spray |
|
Synthetic analogue of the pituitary hormone
vasopressin (ADH). DDAVP Nasal Spray delivers 0.1 mL (10 µg) of DDAVP (desmopressin
acetate) per spray. Dosage (adults): Primary Nocturnal Enuresis: Dosage should be adjusted according to the individual. Initial dose: > 6 years of age: 20 µg (0.2 mL) solution intranasally at bedtime. Adjustment up to 40 µg is suggested if the patient does not respond. Some patients may respond to 10 µg and adjustment to that lower dose may be done if the patient has shown a response to 20 µg. It is recommended that one-half of the dose be administered per nostril. Adequately controlled studies with intranasal DDAVP in primary nocturnal enuresis have not been conducted beyond 4-8 weeks. Diabetes Insipidus: Dosage must be determined for each individual patient and adjusted according to the diurnal pattern of response. The usual dosage range in adults is 0.1 to 0.4 mL daily, either as a single dose or divided into two or three doses. Most adults require 0.2 mL daily in two divided doses. |
flunisolide (Nasalide ®) |
| Start: 2 sprays twice daily. Maximum: 8 sprays/day. |
fluticasone (Flonase ® ) |
|
Seasonal & perennial allergic rhinitis: Adults: Start: 2
sprays (50 mcg of ticasone propionate each) in each nostril qd.
(total: 200 mcg/day). Alternatively: 1 spray each nostril bid. After the first few days, patients may be able to reduce their dosage to 100 mcg (1 spray in each nostril) once daily for maintenance therapy. The maximum total daily dosage should not exceed 2 sprays in each nostril (200 mcg/day). |
Ipratropium bromide (Atrovent Nasal ®) |
|
Dosage (adults):
2 sprays 2 to 4 times per day. [rhinitis: 0.03%,
colds:0.06%] Common cold rhinorrhea: Recommended dose (Nasal Spray 0.06%): 2 sprays (84 mcg) per nostril 3-4 times daily in adults and children age 12 years and older. Seasonal Allergic Rhinitis: 2 sprays (84 mcg) per nostril 2 to 4 times daily in adults and children age 5 years and older. The safety and effectiveness of the use of Atrovent Nasal ® Spray 0.06% beyond 4 days in patients with the common cold or beyond 3 weeks in patients with seasonal allergic rhinitis has not been established. MOA: Anticholinergic agent - inhibits secretions from the serous and seromucous glands lining the nasal mucosa. [Supplied: 0.03% and 0.06% Nasal Spray] |
mometasone (Nasonex ® ) |
| Allergic Rhinitis: Dosing: 2 sprays in each nostril once daily. |
oxymetazoline (Afrin ®) |
| Nasal decongestant. Dosing: Use 2-3 sprays in each nostril twice daily. Maximum use: 72 hours. |
phenylephrine (Neo-Synephrine ®) |
| Nasal decongestant. Dosing: Use 2-3 sprays per nostril every 4 hours as needed. Supplied: [0.125, 0.25, 0.5, & 1 %] |
Saline nasal spray (Ocean ®, SeaMist ® ) |
| Dry nasal passages. Dosing: Use 1-3 sprays in each nostril as needed. |
Sumatriptan (Imitrex ®) |
|
May increase blood pressure and should not be given to patients with
uncontrolled hypertension. The safety of treating an average of more than 4 headaches in a 30-day period has not been established. Serotonin (5-HT 1) agonist --> vasoconstriction of cranial arteries. Dosing (Adults): Acute treatment of migraine: Single doses of 5, 10, or 20 mg administered into 1 nostril are effective for the acute treatment of migraine in adults. Individualize dose based on response. A 10-mg dose may be achieved by the administration of a single 5-mg dose in each nostril. There is evidence that doses above 20 mg do not provide a greater effect than 20 mg. If the headache returns, the dose may be repeated once after 2 hours, not to exceed a total daily dose of 40 mg. Supplied: Nasal Spray 5 mg and 20 mg are each supplied in boxes of 6 nasal spray devices. Each unit dose spray supplies 5 and 20 mg, respectively, of sumatriptan. |
triamcinolone (Nasacort ®) |
|
Dosing (Adults): Use 2 sprays in each nostril once or twice daily. Maximum: 8 sprays/day. Nasacort AQ ® Use 2 sprays in each nostril once daily. |
Zolmitriptan (Zomig ® ) |
|
Serotonin agonist: (5-HT1B and 5-HT1D receptors) -->
vasoconstriction in cranial. Dosing (Adults): Nasal spray: Initial: 1 spray (5 mg) at the onset of migraine headache. If the headache returns, the dose may be repeated after 2 hours; do not exceed 10 mg within a 24-hour period. Controlled trials have not established the effectiveness of a second dose if the initial one was ineffective. |
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Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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GlobalRPH does not directly or indirectly practice medicine or provide
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kind for the information and data accessed through the Service or for
any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
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