Usual starting dose: 500mg po bid or 850 mg po qd. Dosage increases should be
made in increments of 500 mg weekly or 850 mg q2 weeks, up to a total of 2000 mg
per day, given in divided doses. (Maximum: 2550mg/day).
Glucophage XR: Starting dose: 500 mg qd with the evening meal. Dosage increases
should be made in increments of 500 mg weekly, up to a maximum of 2000 mg daily
with the evening meal.
Contraindicated: Males with a serum creatinine > 1.5 mg/dl or
females >1.4 mg/dl.
Also patients with an abnormal creatinine clearance (~ <60-70 ml/min).
Metformin use is contraindicated.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
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