Usual starting dose: 500mg po bid or 850 mg po qd. Dosage increases should be
made in increments of 500 mg weekly or 850 mg q2 weeks, up to a total of 2000 mg
per day, given in divided doses. (Maximum: 2550mg/day).
Glucophage XR: Starting dose: 500 mg qd with the evening meal. Dosage increases
should be made in increments of 500 mg weekly, up to a maximum of 2000 mg daily
with the evening meal.
Contraindicated: Males with a serum creatinine > 1.5 mg/dl or
females >1.4 mg/dl.
Also patients with an abnormal creatinine clearance (~ <60-70 ml/min).
Metformin use is contraindicated.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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