Meperidine
Demerol ® |
| Usual
Dosing (Adults) |
|
Oral: Initial: Opiate-naive: 50 mg q 3-4 hours prn. Usual range: 50-150 mg
q2-4 hours prn.
IM, SC: Initial: Opiate-naive: 50-75 mg q 3-4 hours prn.
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| Renal
Dosing |
Meperidine is not recommended for the management of chronic pain. When used for acute pain (in patients
without renal or CNS disease), treatment should be limited to 48 hours and doses should not exceed 600 mg/24 hours.
[CRCL >50 ml/min]: Usual doses. Limit therapy to 48hr
and do not exceed 600 mg/24 hours.
[10-50 ml/min]: Avoid use. Note: Repeated use in renal impairment should be avoided due to potential accumulation of neuroexcitatory
metabolite normeperidine. Alternatively,
cautiously administer 75% of normal dose and limit
therapy to 24-48hr. Also, daily dose should not exceed
400-450 mg/24 hours.
[<10 ]: Avoid use.
Note: Repeated use in renal impairment should be avoided due to potential accumulation of neuroexcitatory
metabolite normeperidine. Alternatively,
cautiously administer 50% of normal dose and limit
therapy to 24hr. Also, daily dose should not exceed
200-300 mg/24 hours.
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| Hemodialysis |
| Avoid use. |
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