Lamivudine
Epivir ®
Lamivudine/Zidovudine
Combivir ® |
| Usual
Dosing (Adults) |
|
HIV: 150mg po q12h or 300mg po qd.
Hepatitis B (Epivir-HBV ®): 100mg po qd.
Combivir ®: [150mg lamivudine/ 300mg AZT]: 1 tablet bid.
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| Renal
Dosing |
Lamivudine-Epivir ®:
HIV:
[CRCL > 50]: No changes
[30-49]: 150mg po qd.
[15-29]: 150mg po x 1, then 100mg po qd.
[5-14]: 150mg x 1, then 50mg qd.
[<5]: 50mg x 1, then 25mg qd.
Hepatitis B:
[CRCL > 50]: No changes
[30-49]: 100mg po x 1, then 50mg po qd.
[15-29]: 100mg po x 1, then 25mg po qd.
[5-14]: 35mg po x 1, then 15mg po qd.
[<5]: 35mg po x 1, then 10mg po qd.
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Lamivudine/Zidovudine - Combivir ®:
[CRCL >50 ml/min]: No changes.
[<50]:Give each agent separately and adjust based on respective renal dosing guidelines.
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| Hemodialysis |
Lamivudine-
Epivir ®:
HIV: 50mg x 1, then 25-50mg qd.
Hepatitis B: 35mg po x 1, then 10mg po qd.
Lamivudine/Zidovudine -
Combivir ®:
Give each agent separately and adjust based on respective renal dosing guidelines. |
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