Imipenem/cilastatin
Primaxin ® |
| Usual
Dosing (Adults) |
|
250mg to 1gm q6 to 8h
(Maximum dose is 50mg/kg/day or 4 grams/day, whichever is lowest . Give in divided doses)
|
|
| Renal
Dosing |
[CRCL >71]: No changes.
[41 –70 ]: Max 37.5 mg/kg/day or 3 grams/day. (Range: 9.4 – 37.5mg/kg/day) divided q6-8h.
[21-40]: Max 25 mg/kg/day or 2 grams/day. (Range: 6.25 – 25 mg/kg/day) divided q6-12h.
[6-20 ]: Max 12.5 mg/kg/day (max dose 1 gram/day). Range: 6.25 – 12.5 mg/kg/day) divided q12h.
(Usual: 250mg q12h)
|
|
| Dialysis |
Hemodialysis:
125 – 500 mg q12h. (Max 12.5 mg/kg/day). Give dose
after dialysis.
PD: 125 – 250 mg q12h |
|
|
