Imipenem/cilistatin Primaxin ®

Usual Diluents

NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[0 to 500 mg] [100 ml] [30 min] [up to 1 gram] [250 ml] [60 min]

Stability / Miscellaneous

EXP: 4 HRS (RT) / 24 HRS (REF). Label: Refrigerate.  Usually restricted to one of the following:  (1) Serious nosocomial infections, especially those involving resistant organisms; polymicrobial infections (mixed gram pos/negative + anaerobes).  (2) As an alternative to combination therapy for serious intra-abdominal infections. It is used alone, thus avoiding the ototoxic & nephrotoxic effects of amino-glycosides.  (3) Pseudomonas infections caused by organisms resistant to both piperacillin & Fortaz.  IM injection: 500 mg/ 2ml (1% lidocaine) forms a suspension-shake well.  Dosing: Mild to moderate infection: 250-500mg ivpb q6-8h. Severe infection: 500mg to 1g ivpb q6-8h. Max dose/day= 50mg/kg/day or 4g/day.