Imipenem/cilistatin
Primaxin ® |
| Usual
Diluents |
| NS |
| Standard
Dilutions [Amount of drug]
[Infusion volume] [Infusion rate] |
[0 to 500 mg] [100 ml] [30 min]
[up to 1 gram] [250 ml] [60 min]
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| Stability
/ Miscellaneous |
EXP: 4 HRS (RT) / 24 HRS (REF). Label: Refrigerate.
Usually restricted to one of the following:
(1) Serious nosocomial infections, especially those involving resistant organisms; polymicrobial infections (mixed gram pos/negative + anaerobes).
(2) As an alternative to combination therapy for serious intra-abdominal infections. It is used alone, thus avoiding the ototoxic & nephrotoxic effects of amino-glycosides.
(3) Pseudomonas infections caused by organisms resistant to both piperacillin &
Fortaz.
IM injection: 500 mg/ 2ml (1% lidocaine) forms a suspension-shake well.
Dosing: Mild to moderate infection: 250-500mg ivpb q6-8h. Severe infection: 500mg to 1g ivpb q6-8h. Max dose/day= 50mg/kg/day or 4g/day. |
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