Serum sodium level corrected for hyperglycemia

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Correction of serum sodium level in hyperglycemia
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Current Sodium level: meq/L

Current Glucose level: mg/dl

Background

"In marked hyperglycemia, ECF osmolality rises and exceeds that of ICF, since glucose penetrates cell membranes slowly in the absence of insulin, resulting in movement of water out of cells into the ECF. Serum Na concentration falls in proportion to the dilution of the ECF, declining 1.6 mEq/ L for every 100 mg/dL (5.55 mmol/L) increment in the plasma glucose level above normal. This condition has been called translational hyponatremia because no net change in total body water (TBW) has occurred. No specific therapy is indicated, because Na concentration will return to normal once the plasma glucose concentration is lowered."
Source: http://www.merck.com/mrkshared/mmanual/section2/chapter12/12b.jsp

Equation

Corrected Sodium
= Measured sodium + (((Serum glucose - 100)/100) x 1.6)
Alternatively (equivalent equation):
= Measured sodium + 0.016 x (Serum glucose - 100)

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.

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