Acute Hepatic encephalopathy or portosystemic encephalopathy (PSE):
Adults: Oral: 20-30 g (30-45 ml) every 1-2 hours to induce rapid laxation.
Adjust dosage daily to produce 2-3 soft stools. Doses of 30-45 ml may be given
hourly to cause rapid laxation, then reduce to recommended dose.
Usual daily dose: 60-100 g (90-150 mL) daily. Rectal administration: 200 g (300
ml) diluted with 700 ml of H20 or NS - administer rectally via rectal balloon
catheter and retain 30-60 minutes every 4-6 hours
Neomycin (secondary agent)
Hepatic encephalopathy: Oral: 500 to 2000 mg every 6 to 8 hours
or 4 to 12 g/day divided every 4 to 6 hours for 5 to 6 days.
Chronic hepatic insufficiency: Oral: 4 g/day for an indefinite