GLUCAGON

Usual Diluents

D5W,  NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[Recommended conc: 0.1 mg/ml] [5 mg] [50 ml] [10 mg] [100 ml] [20 mg] [200 ml] May be given as a bolus or continuous infusion (See Comments)

Stability / Miscellaneous

Stability: Reconstituted solutions should be used immediately; any unused portion should be discarded.  Use diluent provided only if dose is < 2 mg otherwise dilute vials with sterile water or D5W to prevent phenol toxicity.  After all of the vials have been reconstituted, follow the dilutions listed above: eg 10mg/100 ml D5W or NS. Beta-blocker overdose:  Separate glucagon receptors stimulate adenylcyclase improving heart rate, blood pressure and conduction defects. Adults: 3 - 5 mg (up to 10 mg) rapid IV push followed by an IV drip of 0.07 mg/kg/hr (usually 1 to 5 mg/hour) (The dose used to increase glucose in hypoglycemic patients is only 0.5 - 1 mg IM, IV, or SC).  Note: bolus dose may be repeated in 10 minutes. Usually causes nausea and vomiting. May give Reglan IV, Compazine or Tigan.  Monitor blood glucose levels in hypoglycemic patients until they are asymptomatic; effective in treating hypoglycemia only if sufficient liver glycogen is present; since liver glycogen availability is necessary to treat hypoglycemic patients, glucagon has virtually no effects on patients in states of starvation, adrenal insufficiency, or chronic hypoglycemia.  Recommended routes: IM, IV, or SC. Half-life: 8 to 18 minutes.