Dosing (Adults): I.M., I.V.:
Systemic infections: Severe, life-threatening infections:
Conventional dosing: 2-2.5 mg/kg/dose every 8-12 hours; to ensure adequate peak
concentrations early in therapy, higher initial dosages may be considered in
selected patients when extracellular water is increased (edema, septic shock,
postsurgical, or trauma)
Once-daily dosing: Some clinicians suggest a daily dose of 4-7
mg/kg once daily for all patients with normal renal function; this dose is at
least as efficacious with similar, if not less, toxicity than conventional
dosing.
Urinary tract infections: 1.5 mg/kg/dose every 8 hours
Prevention of bacterial endocarditis:
Dental, oral, or upper respiratory procedures: 1.5 mg/kg (not to exceed 80 mg)
with ampicillin (1-2 g) 30 minutes prior to procedure
GI/GU surgery: 1.5 mg/kg (not to exceed 80 mg) with ampicillin
(2 g) 30 minutes prior to procedure
Renal Dosing
Dosing interval in renal impairment:
Conventional dosing:
Clcr >/=60 mL/minute: Administer every 8 hours
Clcr 40-60 mL/minute: Administer every 12 hours
Clcr 20-40 mL/minute: Administer every 24 hours
Clcr<20 mL/minute: Loading dose, then monitor levels
High-dose therapy: Interval may be extended (eg, every 48 hours) in
patients with moderate renal impairment (Clcr 30-59 mL/minute) and/or
adjusted based on serum level determinations.
Hemodialysis
Hemodialysis: Dialyzable; removal by hemodialysis: 30% removal of
aminoglycosides occurs during 4 hours of HD; administer dose after
dialysis and follow levels.
Disclaimer
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
judgment. Neither GlobalRPh Inc. nor any other party involved in the
preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER
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