GENTAMICIN

Usual Diluents

NS,  D5W

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[0 to 40 mg] [50 ml] [30 min] [>40mg] [100 ml] [30 min]

Stability / Miscellaneous

EXP: 1 DAY (RT) / 4 DAYS (REF) Increased Vd: CHF, peritonitis, ascites, acute burn, hypo-albuminemia, immediate post partum.  Kel (for gent/tobra/amikacin): (crcl) (0.003) + 0.01  Vd (for gent/tobra/amikacin): 0.3 L/kg ibw or adjusted body if >30% ibw.  Adjusted body wt: (Actual body wt - ibw) (0.4) + ibw.  Dose by levels (target trough): Gent/tobra: < 2 mcg/ml (<3 HD). Amikacin: < 8 mcg/ml (<10 HD). Estimation of dosing interval: Gent/Tobra/Amik: 3 x T1/2 Vanco: 2 x T1/2 (Note: may also solve for (T=dosing interval) using the Cmin equation).  T= [ln (Cmax/Cmin) / Kel] + ti Usual target trough (conventional dosing): Gent/Tobra: 0.5 to 1 mcg/ml // Amikacin: 4-8 mcg/ml.  Monitoring: Scr qod or qd if unstable. Follow clinical response: monitor WBC, Tmax, C&S, I&O's. Obtain levels 30 minutes before and after a 30 min infusion.