Fosphenytoin Cerebyx ®

Usual Diluents

D5W,  NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[100 to 1250 mg PE][50 ml] [10 min or greater] Max rate: 150 mg PE / minute

Stability / Miscellaneous

Water soluble prodrug of phenytoin.  Status epilepticus: loading: 15 to 20 mg PE/kg.  Maintenance dose: 4 to 6 mg PE/kg/day.  Fosphenytoin offers many advantages over phenytoin: minimum phlebitis, complete IM absorption, and the ability to administer the drug much more rapidly.  Cerebyx (IM / IV) can be substituted 1:1 for oral phenytoin.  IM cerebyx is not recommended for tx of status epilepticus.