Fomepizole Antizol ®

Usual Diluents

NS,  D5W

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[Prescribed dose] [100ml] [30 min]

Stability / Miscellaneous

Dosing: loading dose: 15 mg/kg, followed by 10 mg/kg q12h x 4 doses, then 15 mg/kg q12h thereafter until ethylene glycol levels <20 mg/dl.  Dialysis should be considered in addition to fomepizole in the case of renal failure, significant or worsening metabolic acidosis, or a measured ethylene glycol level >50 mg/dl.  Fomepizole is dialyzable and should be given q4h during hemodialysis.  MOA: complexes and inactivates alcohol dehydrogenase thus preventing formation of the toxic metabolites of the alcohols. Supplied: 1 g/ml-1.5 ml vial.