Fluconazole Diflucan ®

Usual Diluents

NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

(ready-to-use) [200 mg] [100 ml] [1 hour] [400 mg] [200 ml] [2 hours]

Stability / Miscellaneous

EXP: 7 DAYS (RT) if solution is transferred.  Label: Do not Refrigerate.  Maximum IV rate: 200 mg/hr.   Oral: Oropharyngeal candidiasis: 200mg orally x 1, followed by 100mg orally once daily. Esophageal candidiasis: 100-200 mg orally once daily (up to 400mg/day). Cryptococcal meningitis: 400mg orally x 1, followed by 200mg orally once daily x 10-12 weeks (Suppression: 50-200mg orally once daily). Onychomycosis: 200-300mg once weekly or 100-200mg orally every other day (further studies needed).   IV: since oral absorption is rapid and essentially complete--IV dose=oral dose.    Renal dosing: >50/ no change || <50 / 50% of usual dose. || Alternatively: 20 to 50/ give normal dose q48h. || <20 / 50% of usual dose q48h. || Hemodialysis: give 100-200mg after each dialysis. || CAPD: give 50% of usual dose at usual interval.