Fibrates

Background

The fibrates, or fibric acid derivatives, act in part to stimulate the activity of peroxisome proliferator-activated receptors (PPARs), which are involved in fatty acid breakdown. The main action of fibrates is to lower triglyceride levels (by 35 to 50 percent). Fibrates also raise serum high density lipoprotein (HDL) by 15 to 25 percent. Fibrates are the drugs of choice when treating isolated elevated triglycerides. They can be combined with statins to treat combinations of high triglycerides and LDL cholesterol.

clofibrate (Atromid-S ®)

Usual dosage (dyslipidemia): 500 mg orally 4 times/day. Some patients may respond to lower doses.

Renal Dosing:
crcl >50 ml/min: Administer every 6-12 hours.
crcl 10-50 ml/min: Administer every 12-18 hours.
crcl <10 ml/min: Avoid use.

Supplied: 500 mg capsule

fenofibrate (Tricor ®):

Initially: 67 mg (1 cap) orally once daily with meal. Maximum: 3 caps once daily.

gemfibrozil (Lopid ®):

Usual dosage: 600mg orally twice daily.

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc.