FENOLDOPAM (CORLOPAM ®)

Usual Diluents

NS,  D5W

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

----Final conc: 40 mcg/ml ----- [10 mg] [250 ml] [Titrate] [20 mg] [500 ml] [Titrate]

Stability / Miscellaneous

EXP: 1 Day (RT).  Indications: Short term treatment (up to 48hrs) of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is indicated. May be discontinued abruptly or tapered gradually.  Dosing: Usual initial rate: 0.1 mcg/kg/min, increased by increments of 0.05 to 0.1 mcg/kg/min at 15-20min intervals until target blood pressure reached. Usual effective doses: 0.1 to 1.6 mcg/kg/min. Generally, lower initial doses (0.03 to 0.1 mcg/kg/min) titrated slowly, have been associated with less reflex tachycardia.  Never given by IV bolus.  MOA: Selective dopamine (D1) agonist which decreases peripheral vascular resistance; increases renal blood flow; increased diuresis and natriuresis. 6 times as potent as dopamine in producing renal vasodilation.  Onset: 10 minutes.  Supplied: 10mg/ml-1&2 ml ampules.