Esmolol Brevibloc ®

Usual Diluents

D5W,  NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[2.5 grams] [250 ml] [Titrate] [5 grams] [500 ml] [Titrate]

Stability / Miscellaneous

EXP: 1 DAY (RT).   Note: the listed dilutions are for the 2.5 gram ampules. If the ampules are not available, the 10 ml (10mg/ml) vials must be transferred to an empty viaflex bag. Do not dilute the contents of the "vial," they are pre-diluted. Dosing: PSVT: 500 mcg/kg over 1 min, then 50 mcg/kg/min x 4 to 5min. If heart rate not controlled, repeat load of 500 mcg/kg and increase infusion to 100 mcg/kg/min. Repeat load and increase infusion q5 to 10min as needed to max of 200 (up to 300?) mcg/kg/min. Watch blood pressure.  Calculation of drip rate (ml/hr): 2.5 grams/250 ml:  wt (kg) x mcg/min x 0.006 Minimum Dilution: Note: The use of esmolol with propylene glycol has been associated with a higher incidence of venous irritation at concentrations greater than 10 mg/mL on continued infusion. Mixed from the ampul at concentrations of greater than 10 mg/mL BREVIBLOC has, however, been well tolerated when administered via a central vein. A premixed bag is available from the manufacturer: 2000 mg/100 ml (solution osmolarity adjusted to 312 mOsmol/L).