Erectile dysfunction

Sildenafil (Viagra ®)

Phosphodiesterase-5 Enzyme Inhibitor.
Dosing (Adults): Start 50 mg orally 0.5 to 4 hours prior to intercourse. The maximum recommended dosing frequency is once daily. Usual effective range: 25 to 100mg. Start at 25mg if >65 years old or liver/renal impairment.
Renal Dosing: Crcl <30 ml/min: Initial: 25 mg, 1 hr before sexual activity.

Supplied: Viagra®: 25 mg, 50 mg, 100 mg tablet.

tadalafil (Cialis ®)

PDE-5 enzyme inhibitor.

Dosing (Adults): Erectile dysfunction: 10 mg orally prior to anticipated sexual activity (dosing range: 5-20 mg) - to be given as a single dose and not given more than once daily (Erectile function may be improved for up to 36 hours following a single dose).

Drug interactions: Alpha blockers: If stabilized on either alpha blockers or tadalafil therapy, initiate new therapy with the other agent at the lowest possible dose. CYP3A4 inhibitors: Dose reduction of tadalafil is recommended with strong CYP3A4 inhibitors. The dose of tadalafil should not exceed 10 mg, and tadalafil should not be taken more frequently than once every 72 hours. Some examples include: (azole antifungals, clarithromycin, doxycycline, erythromycin, grapefruit juice, imatinib, isoniazid, nefazodone, protease inhibitors, others...)

Renal Dosing:
Crcl 31-50 ml/min: Initial dose 5 mg once daily - maximum dose 10 mg not to be given more frequently than every 48 hours.
Crcl <30 ml/min or hemodialysis: Maximum dose 5 mg.

Hepatic impairment:
Mild-to-moderate hepatic impairment (Child-Pugh class A or B): Do not exceed 10 mg once daily.
Severe hepatic impairment: Use is not recommended.

Supplied: 5 mg, 10 mg, 20 mg tablet.

vardenafil (Levitra ®)

PDE-5 enzyme inhibitor.

Dosing (Adults): Erectile dysfunction: 10 mg orally 1 hour prior to sexual activity. Dosing range: 5-20 mg (given as one single dose and not given more than once daily). Patients >/= 65 yrs old: Initial: 5 mg 1 hr prior to sexual activity- to be given as one single dose and not given more than once daily.

Drug interactions: Alpha blocker (dose should be stable at time of vardenafil initiation): Initial vardenafil dose: 5 mg/24 hrs. If an alpha blocker is added to vardenafil therapy, it should be initiated at the smallest possible dose, and titrated carefully. Other: Erythromycin: Max vardenafil dose: 5 mg/24 hrs. Indinavir: Max dose: 2.5 mg/24 hrs. Itraconazole: 200 mg/day: Max dose: 5 mg/24 hours. 400 mg/day: Max dose: 2.5 mg/24 hrs. Ketoconazole: 200 mg/day: Max dose: 5 mg/24 hrs. 400 mg/day: Max dose: 2.5 mg/24 hrs. Ritonavir: Max dose: 2.5 mg/72 hrs.

Hepatic impairment: Child-Pugh class B: Initial: 5 mg 1 hr prior to sexual activity (max dose: 10 mg)- to be given as one single dose and not given more than once daily.

Supplied:: 2.5 mg, 5 mg, 10 mg, 20 mg tablet.

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc.

Disclaimer Contact Us Privacy Policy Website Search	WWe comply with the HONcode standard for health trustworthy information: Verify here. Copyright © 2007 GlobalRPh Inc.