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Percutaneous
Coronary Intervention (PCI): 180 µg/kg IV bolus administered immediately before the
initiation of PCI followed by a continuous infusion of 2.0 µg/kg/min
and a second 180 µg/kg bolus 10 minutes after the first bolus. Infusion
should be continued until hospital discharge, or for up to 18 to 24
hours, whichever comes first. A minimum of 12 hours of infusion is
recommended. Patients weighing more than 121 kg should receive a maximum
of 22.6 mg per bolus followed by a maximum infusion rate of 15 mg per
hour.
Acute
Coronary Syndrome: IV bolus of
180 µg/kg as soon as possible following diagnosis, followed by a
continuous infusion of 2.0 µg/kg/min until hospital discharge or
initiation of CABG surgery, up to 72 hours. If a patient is to undergo a
percutaneous coronary intervention (PCI) while receiving eptifibatide,
the infusion should be continued up to hospital discharge, or for up to
18-24 hours after the procedure, whichever comes first, allowing for up
to 96 hours of therapy. Patients weighing more than 121 kg should
receive a maximum bolus of 22.6 mg followed by a maximum infusion of 15
mg per hour.
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