Dofetilide - Tikosyn ®

Dofetilide - Tikosyn ® - Renal Dosing

Usual Dosing (Adults)

500 mcg po bid initially. May be initiated at lower doses based on physician discretion. QTc interval should be measured 2-3 hours after the initial dose. If the QTc >15% of baseline, or if the QTc is >500 msec (550 msec in patients with ventricular conduction abnormalities), dofetilide should be adjusted. Continued monitoring for doses 2-5: QTc interval must be determined 2-3 hours after each subsequent dose of dofetilide for in-hospital doses 2-5. If the measured QTc is >500 msec (550 msec in patients with ventricular conduction abnormalities) dofetilide should be stopped.

Renal Dosing

[CRCL >60 ml/min]: 500 mcg bid

[40-60 ml/min]: 250 mcg twice daily.

[20-39 ml/min]: 125 mcg twice daily.

[<20 ml/min]: Contraindicated.

Hemodialysis

Contraindicated

Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer

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