 |
Diuretics
Acetazolamide (Diamox ® ) |
|
Class: Carbonic anhydrase inhibitor Glaucoma: 250mg qd - qid or 500mg SR bid. Secondary (acute) closed angle: IV: 250-500mg. May rpt in 2-4 hrs to a Maximum of 1 gram. Edema: 250-375 mg po qd in the morning for 1 or 2 days, alternating with day of rest (reduce resistance). Epilepsy: 8-30 mg/kg po daily, divided q8-12h. Urine alkalinization (unlabeled use): Oral: 5 mg/kg/dose repeated 2-3 times over 24 hours. Metabolic alkalosis (unlabeled use): I.V. 250 mg every 6 hours for 4 doses or 500 mg single dose; reassess need based upon acid-base status. Respiratory stimulant in COPD (unlabeled use): Oral, I.V.: 250 mg twice daily. [Supplied: 125, 250 mg tablet. 500mg SR capsule. 500mg powder for injection.] |
Amiloride (Midamor ® ) |
|
Class: Potassium sparing Diuresis: Start 5 mg po qd. Maintenance: 5-20 mg po qd. Maximum: 20mg/day. [Supplied: 5 mg tab] |
Amiloride and HCTZ (Moduretic ®) |
|
Class: Combination Potassium sparing and Thiazide Adult (usual) - Diuresis: 1 tab po daily - may increase to 2 tabs po daily. [Supplied: 5mg amiloride/50mg(hctz) tablet] |
Bendroflumethiazide (Naturetin ® ) |
|
Class: Thiazide Adult (usual) Edema: initial, up to 20 mg po daily (divided once or twice daily). Maint: 2.5-5 mg po qd. Hypertension: initial, 5-20 mg po daily (divided once or twice daily). Maint: 2.5-15 mg po qd. Avoid use in pts with SCR >2.5 mg/dl. [Supplied: 2.5, 5, 10 mg tablet] |
Bumetanide (Bumex ® ) |
|
Class: Loop Diuretic Edema (adult): 0.5-2 mg po qd - maximum 10 mg/day. Edema: 0.5-1 mg IV or IM, given over 1-2 min; can give a second and third dose at intervals of 2-3 hr to maximum of 10 mg/day. Continuous I.V. infusion: 0.9-1 mg/hour. Hypertension: Oral: 0.5 mg daily (range: 1-4 mg/day, maximum dose: 5 mg/day); for larger doses, divide into 2-3 doses daily. Administer I.V. slowly, over 1-2 minutes. An alternate-day schedule or a 3-4 daily dosing regimen with rest periods of 1-2 days in between may be the most tolerable and effective regimen for the continued control of edema. [Supplied 0.25 mg/ml soln for inj. 0.5, 1, 2 mg tablet] |
Chlorothiazide (Diuril ® ) |
|
Class: Thiazide HTN: 500 mg - 1000 mg mg po qd or divided bid. Edema: 500 - 1000 mg po or IV qd or bid - may give every other day or 3-5 days each week. [Supplied: 250, 500mg tablet. 250mg/5ml suspension.] |
Chlorthalidone (Hygroton ® ) |
|
Class: Thiazide Edema: initial, 30-60 mg po qd or 60 mg qod; some patients may require up to 120 mg daily. Alternatively: 50-100 mg po qd or 100mg po qod or 100mg 3 times per week. Maximum: 200mg /day. Hypertension: initially: 12.5 to 25 mg po qd. Usual maint: 12.5 to 50mg /day. Maximum: 50mg qd. Alternatively: initially 15 mg po qd. Usual Maint: 30-45 mg/day. [Supplied 15, 25 mg compressed tablet. 50, 100mg scored tablet.] |
Dichlorphenamide ( Daranide ®) |
|
Class: Carbonic anhydrase inhibitor Adults: Oral: 100-200 mg to start followed by 100 mg every 12 hours until desired response is obtained; maintenance dose: 25-50 mg 1-3 times per day. [Supplied: 50 mg tablet] |
Eplenerone (Inspra ®) |
|
Class: Potassium sparing HTN: Initial: 50 mg qd - may increase to 50 mg bid if response is not adequate. May take up to 4 weeks for full therapeutic response. Doses >100 mg/day are associated with increased risk of hyperkalemia and no greater therapeutic effect. Concurrent use with weak CYP3A4 inhibitors: Initial: 25 mg qd. Renal Dosing: Contraindicated with Clcr<50 ml/minute or serum creatinine >2.0 mg/dl in males or >1.8 mg/dl in females ( risk of hyperkalemia increases with decreased renal function). |
Ethacrynic acid (Edecrin ®) |
|
Class: Loop Diuretic SODIUM EDECRIN should not be given SC or IM because of local pain and irritation. Edema (adult): Oral: 50-100 mg/day in 1-2 divided doses; may increase in increments of 25-50 mg at intervals of several days to a maximum of 400 mg/24 hours. (ELDERLY — Oral: Initial: 25-50 mg/day.) IV: Usual: 50mg x 1 (0.5-1 mg/kg/dose). Maximum: 100 mg/dose. Usually only one dose has been necessary; occasionally a second dose at a new injection site, to avoid possible thrombophlebitis, may be required. A single intravenous dose not exceeding 100 mg has been used in critical situations. Preparation: Dilute in D5W or NS (1 mg/mL) and infuse over several minutes. [Supplied: 50 MG powder for inj. 25, 50mg tablet] |
Furosemide (Lasix ® ) |
|
Class: Loop Diuretic Edema: initial: 20-40 mg IV/IM over 1-2 min. May repeat in 1 to 2 hours or may be increased by 20 mg until desired response. This individually determined dose may be given once or twice daily. Edema (oral): initial: 20-80 mg po qd - may repeat in 6-8 hrs. Maximum: 600 mg/day. HTN: initial: 80 mg po daily (divided twice daily). CHF: 250 to 4000 mg daily (IV or PO) Acute pulmonary edema: usual dose - 40 mg IV over 1-2 minutes. If not adequate, may increase dose to 80 mg. Continuous I.V. infusion: Initial IV bolus dose of 0.1 mg/kg followed by continuous I.V. infusion doses of 0.1 mg/kg/hour doubled q2h to a maximum of 0.4 mg/kg/hour if urine output is <1 ml/kg/hour. Other studies have used a rate of 4 mg/minute as a continuous IV infusion. Elderly: Oral, IM, IV: Initial: 20 mg/day; increase slowly to desired response. Refractory heart failure: Oral, IV: Doses up to 8 g/day have been used. Acute renal failure: High doses (up to 1-3 g/day - oral/IV) have been used to initiate desired response. Avoid use in oliguric states. Administration: IV injections should be given slowly over 1-2 minutes. Maximum rate of administration for IVPB or infusion: 4 mg/minute. Replace parenteral therapy with oral therapy as soon as possible. [Supplied 10 mg/ml, 40 mg/5 ml oral soln. 10 mg/ml soln for inj. 20,40, 50, 80mg tablet] |
Hydrochlorothiazide (Esidrix ®, HydroDiuril ®, Microzide™) |
|
Class: Thiazide Edema: 25-100 mg po daily in single or divided doses. Hypertension (HTN): initial, 12.5-25 mg po once daily. Titration: allow 2-3 weeks to achieve optimum antihypertensive effect. Usual maintenance dose: 12.5 - 50mg/day. Maximum 50mg/day. Renal Dosing: GFR less than 15-25 mL/min, use not recommended. Patients with edema may respond to intermittent therapy (ie, administer on alternate days or 3-5 days / week). [Supplied: 25, 50, 100mg tablet. 12.5 mg capsule. 50mg/5 ml solution] |
HCTZ /Triampterene (Dyazide ®, Maxzide ®) |
|
Class: Combination Potassium sparing and Thiazide HTN: initial, 1 tab or capsule (25 mg hydrochlorothiazide/37.5 mg triamterene) po qd. Allow 2-3 weeks to achieve optimum antihypertensive effect. May increase to maximum dose of 50/75 mg po qd (higher doses increase the risk of electrolyte imbalance and renal dysfunction). [Supplied 25 mg-37.5 mg capsule/tablet. 50 mg-75 mg tablet]. |
Hydroflumethiazide ( Diucardin ®) |
|
Class: Thiazide Edema: usual - 50 to 100 mg daily initially. Doses of 25 or 200 mg daily are used for maintenance therapy. HTN: usual adult dose - 12.5 to 50 mg daily. [Supplied: 50mg tablet] |
Indapamide (Lozol ® ) |
|
Class: Thiazide Edema: initial: 2.5 mg po qd in the morning - may increase to 5 mg po qd after 1 week. HTN: initial: 1.25 mg po qd in the morning. Titration: allow 4 weeks to achieve optimum antihypertensive effect. Maintenance: 2.5-5 mg po qd. [Supplied 1.25, 2.5 mg tablet] |
Methazolamide (Neptazane ®) |
|
Class: Carbonic anhydrase inhibitor Adult (usual) - Glaucoma: 50-100 mg po bid - tid. Altitude sickness: 150-200 mg po daily. [Supplied: 25, 50 mg tablet] |
Methyclothiazide (Enduron ® ) |
|
Class: Thiazide Edema: Initially: 2.5mg po qd. Range: 2.5-10 mg po qd. Hypertension: 2.5-5 mg po qd. [Supplied: 2.5, 5mg tablet] |
Metolazone (Zaroxolyn ®, Mykrox ®) |
|
Class: Thiazide Edema: initial, 5-10 mg po qd. May increase up to 20mg in renal disease. HTN: 2.5-5 mg po qd (Maximum: 10mg po qd). HTN (Mykrox®): initial, 0.5 mg po qd. Maximum: 1 mg/day. HTN (Zaroxolyn®): 2.5 - 5 mg po qd (Maximum: 10mg/day). [Supplied: Mykrox® 0.5 mg tablet. Zaroxolyn®: 2.5, 5, 10mg tablet] |
Polythiazide (Renese ®) |
|
Class: Thiazide Edema (Adult): 1-4 mg po qd. HTN: 2-4 mg po qd. [Supplied: 1, 2, 4 mg tablet] |
Spironolactone (Aldactone ® ) |
|
Class: Potassium sparing Edema (cirrhosis, nephrotic syndrome): initial, 100 mg po qd or divided bid - after 5 days if response is inadequate, adjust dosage (Maximum: 400 mg/day). (Maint range: 25-200 mg/day in single or divided doses). Consider adding another diuretic if response is inadequate. Hirsutism in women: 50-200 mg po daily OR 200 mg/day po for 20 days per month; duration of therapy, several months up to 1 yr. Hyperaldosteronism (diagnosis): long test, 400 mg po daily for 3-4 weeks; short test, 400 mg po daily for 4 days. Hyperaldosteronism (treatment): 100-400 mg/day po (use lowest effective dosage). Hypertension: Start: 50-100 mg/day po in 1-2 divided doses; continue for 2 weeks, then adjust to response (Maximum: 400 mg/day). Elderly: Initial: 25-50 mg/day in 1-2 divided doses, increasing by 25-50 mg every 5 days as needed. Renal Dosing: Renal impairment: crcl 10-50 mL/minute: Administer every 12-24 hours. crcl <10 ml/minute: Avoid use. [Supplied: 25, 50, 100mg tablet] |
Spironolactone and HCTZ (Aldactazide ®) |
|
Class: Combination Potassium sparing and Thiazide Adults: (25/25mg tablet): 0.5 to 8 tablets qd. (50/50 mg tablet): 0.5 to 4 tablets qd in 1-2 doses [Supplied: 25/25mg and 50/50mg tablets]. |
Torsemide (Demadex ® ) |
|
Class: Loop Diuretic Edema (CHF): initial: 10-20 mg po or IV qd. Maintenance: may increase by doubling the dose. Maximum: 200 mg po or IV qd. Edema (liver disease): initial: 5-10 mg po or IV qd along with an aldosterone antagonist or potassium-sparing diuretic. Edema (renal failure): initial 20 mg po or IV qd. Maintenance: may increase by doubling the dose. Maximum: 200 mg po or IV qd. (HTN): initial 5 mg po qd. Allow 4-6wk to achieve optimum antihypertensive effect. May increase to 10 mg po qd. [Supplied: 10 mg/ml injection. 5, 10, 20 , 100mg tablet] |
Trichlormethiazide (Naqua ®) |
|
Class: Thiazide HTN/Edema: Initially - 2 mg po qd. Usual Maint: 2-4 mg po qd. [Supplied: 4 mg tablet] |
Triamterene (Dyrenium ®) |
|
Class: Potassium sparing Edema (cirrhosis, CHF, nephrotic syndrome) / HTN: Start: 100 mg po daily in 1-2 divided doses. (Maximum: 300 mg po daily). [Supplied: 50, 100mg capsule]. |
Disclaimer |
|
Listed dosages are for - Adult patients ONLY. PLEASE READ THE
DISCLAIMER CAREFULLY BEFORE
ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE
TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
GlobalRPH does not directly or indirectly practice medicine or provide
medical services and therefore assumes no liability whatsoever of any
kind for the information and data accessed through the Service or for
any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
| Disclaimer Contact Us Privacy Policy Website Search | We comply with the HONcode standard for health trustworthy information: Verify here. Copyright © 2007 GlobalRPh Inc. |
 |
 |