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Latest Intravenous Dilution Guidelines


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Dilution List     [ B ]
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Drug Standard  Dilution Infusion Rate Diluents*
BACTRIM 0 to 80 mg/ 100 ml
81 to 120 mg/ 150-250 ml
121 to 240 mg/ 250 ml
241 to 450 mg/ 500 ml
60 min
90 min
90 min
2 hours
D5W
Stability/Misc.

EXP: 6 hours (RT)/ 2hrs (minimum dilution).   Label: Do not Refrigerate.   Minimum dilution: 80 mg TMP/ 75 ml.  IV: Usual dose: 8-10mg/kg/day divided q6h, q8h or q12h. PCP: 15-20mg/kg/day in 3 or 4 divided doses. Note: dosages are based on trimethoprim.   Oral: UTI: 1 DS tab (160mg TMP/800mg SMX) po q12h. 
Renal Dosing:
>30/ no change || 15-30/ 50% of usual dose q12h-alternatively: 8-10mg/kg/day divided q12h x 1-2 days, then 4-6mg/kg q24h. || <15/ not recommended by manufacturer. Alternatively: 8-10mg/kg/dose q48h or 4-6 mg/kg/day.
 
BRETYLIUM (BRETYLOL) 500 mg/ 50-100 ml
2 grams/ 250 ml
Titrate D5W  / NS
Stability/Misc.

EXP: 1 Day (RT). Usual continuous infusion rate: 1-2 mg/min (0.5 to 4 mg/min) Dosing: initially 5 mg/kg bolus. IF V-fib persists: 10 mg/kg bolus. Repeat q5-10min up to total (30 to 35 mg/kg). Vtach: 5-10mg/kg diluted in 50ml over 8-10min or longer. May rpt q1-2h if arrhythmia persists. Renal impairment: 10-50/ 50% of dose. <10/ 25% of dose. Side effects: bradycardia/hypotension/ N&V. [Supplied: 500mg/ 10ml syringe] Calculation of drip rate: (code blue: 1 gram/500 ml D5W: 1 mg/min= 30 ml/hr )
 
BUMETANIDE (BUMEX) 25 mg(100ml)/ empty viaflex Titrate D5W  / NS
Stability/Misc.

EXP: 1 Day (RT). May add 0 to 25 mg/100 to 250 ml D5W/NSS, Supplied: 2.5mg/ 10 ml vial. Equivalent dosages: [1 mg Bumex] =[40mg Lasix] = [10 to 20mg Demadex]. Higher doses are req'd in renal failure (usually > 10 mg/day). Usual infusion rates: 0.1 to 1 mg/hr.

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The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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