Digoxin IMMUNE FAB Digibind ®

Usual Diluents

NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[Prescribed dose/ 50 ml]  [30 min] (Must use 0.22 micron filter). Improvement in signs and symptoms usually begins in 30 minutes or less.

Stability / Miscellaneous

Stability: Use promptly after mixing (may refrigerate up to 4 hours). Reconstitution: Dissolve each vial with 4 ml sterile water (do not shake). May be further diluted with normal saline.     Infuse over 30 minutes-- must use 0.22 micron filter. If cardiac arrest is imminent, may give as a bolus.   Number of vials needed =[(steady state serum digoxin level (ng/ml) x weight (kg)] / 100. Each vial contains 38 mg which will bind approximately 0.5 mg of digoxin.  Dosage for acute ingestion of unknown amount: 20 vials (760mg) of Digibind is adequate to treat most life-threatening ingestions.  May consider giving 10 vials, observing the patient's response, and following with an additional 10 vials.  Dosage for toxicity during chronic therapy: for adults, 6 vials (228mg) usually is adequate to reverse most cases of toxicity. This dose can be used in patients in acute distress or when a serum concentration is not available.