DESMOPRESSIN (DDAVP ®)

Usual Diluents

NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[0 to 35 mcg/ 50 ml] [15 - 30min]

Stability / Miscellaneous

Supplied: 4 mcg/ml-1 ml vial.  Indications: Hemophilia (increases factor VIII levels): 0.3 mcg/kg in 50ml normal saline over 15-30 minutes.  Diabetes insipidus: 2-4 mcg/day IV push or SC. Decrease bleeding following cardiac bypass: 0.3 mcg/kg ivpb.   Provide short term protection for uremic hemorrhagic tendency: 0.3 mcg/kg ivpb q8h x 2 doses (diminishing response).  Greatly enhanced ADH activity. Less vasopressor activity. Longer DOA. (Synthetic analog of vasopressin-posterior pituitary hormone).  ADH activity : Pressor activity  [DDAVP: 2000-4000: 1   Vasopressin: 1:1]