Dantrolene
Dantrium ® |
| Usual
Diluents |
|
| Standard
Dilutions [Amount of drug]
[Infusion volume] [Infusion rate] |
[20 mg vial] [60 ml sterile water without a bacteriostatic agent]
Infusion rate: as directed
|
|
| Stability
/ Miscellaneous |
Dantrium is
given by direct injection and is incompatible
with D5W or NS. Prepare just before
use.
EXP: 6hours (RT).
Tx severe muscle rigidity: 1 mg/kg rapid iv push,
may repeat q1-3min until muscle relaxation or total dose
of 10 mg/kg. When pt can tolerate po may substitute 1-2
mg/kg po qid. If refractory (NMS) consider adding
bromocriptine 5 mg tid initially -if response is
inadequate, increase dose rapidly to max of 10-20 mg po
q6h. D/C when pt improves or CPK (nml).
Prevention of malignant hyperthermia: 2.5 mg/kg IV
over 1 hr approximately 75 minutes prior |
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