EXP: 2 DAYS (RT) / 10
DAYS (REF). Label: Refrigerate.
Maximum
dose/day: 4800 mg. May be given IM.
Usual
oral dose:
150-450mg po q6h (take with a full glass of water to reduce risk
of esophageal irritation/erosion).
Usual IV dose:
600mg IV q6-8h or 900mg
ivpb q8h.
Maximum daily dose= 4800mg.
Maximum infusion rate:
30 mg/min.
Renal Dosing: No
dosage adjustments req'd for renal failure.
Package
insert:
Adults: Parenteral (IM or IV
Administration): Serious infections due to aerobic gram-positive cocci
and the more susceptible anaerobes (NOT generally including
Bacteroides fragilis, Peptococcus species and Clostridium species
other than Clostridium perfringens ): 600-1200 mg/day in 2, 3 or 4 equal
doses. (Usual: 300 mg IV q6 or 8 hours.)
More
severe infections, particularly those due to proven or suspected Bacteroides
fragilis, Peptococcus species, or Clostridium species other than
Clostridium perfringens : 1200-2700 mg/day in 2, 3 or 4 equal doses. For
more serious infections, these doses may have to be increased.
(Usual: 600mg IV q6 or 8h or 900 mg IV q8h.)
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