Cisatracurium
Nimbex ® |
| Usual
Diluents |
| NS,
D5W |
| Standard
Dilutions [Amount of drug]
[Infusion volume] [Infusion rate] |
(Useing 200mg/20 ml vial)
Titrate
[200 mg/ 180 ml] (total vol=200ml)
[100 mg/ 90 ml] (total vol= 100 ml)
(Using 2 mg/ml vials)
Titrate
[40 mg/ 80 ml] (Total vol=100 ml)
[100 mg/ 200 ml] (Total vol=250 ml)
[200 mg/ 400 ml] (Total vol=500 ml)
(Concentration= 0.4 mg/ml)
(May also be given undiluted)
|
|
| Stability
/ Miscellaneous |
EXP: 1 DAY
(RT/REF).
[Supplied: 10mg/ 5ml and 20 mg/10 ml vials (In refrigerator)]. Usual
dilution: 0.1 to 0.4 mg/ml.
Dosing:
Intermittent: initial
dose: 0.15 to 0.2 mg/kg IV bolus followed by 0.03 mg/kg IV q40-60min.
Continuous infusion: 0.1 to 0.2 mg/kg IV bolus followed by 1
to 3 mcg/kg/min. The average infusion rate for long term use in the ICU
is approximately 3 mcg/kg/min (range: 0.5 to 10.2 mcg/kg/min). In some
cases, re-administration of the bolus dose may be req'd while titrating.
Dosage reductions are not required in renal or hepatic failure.
Drug of choice in the following cases (1) hemodynamically
significant increases in HR (e.g. >20%) while paralyzed with
pancuronium or MAP>110. (2) Concurrent corticosteroid administration
(>72hrs) (3) Significant renal dysfunction (CRCL < 30 ml/min)
(4) History of asthma or bronchospasm. |
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