Ciprofloxacin (CIPRO) - Renal dosing

Usual Dosing (Adults)

(Oral): 250- 750mg q12h.

(IV): 200-400 mg IV q12h.
[Febrile neutropenia]: 400 mg IV q8h.

DOSAGE AND ADMINISTRATION – ADULTS
Ciprofloxacin injection should be administered to adults by intravenous infusion over a period of 60 minutes at dosages described in the Dosage Guidelines table. Slow infusion of a dilute solution into a larger vein will minimize patient discomfort and reduce the risk of venous irritation. (See Preparation of Ciprofloxacin Injection for Administration section.)

The determination of dosage for any particular patient must take into consideration the severity and nature of the infection, the susceptibility of the causative microorganism, the integrity of the patient’s host-defense mechanisms, and the status of renal and hepatic function.
ADULT DOSAGE GUIDELINES

Infection*	Severity	Dose	Frequency	Usual Duration
Urinary Tract	Mild/Moderate	200 mg	q12h	7-14 Days
	Severe/Complicated	400 mg	q12h	7-14 Days
Lower Respiratory	Mild/Moderate	400 mg	q12h	7-14 Days
Tract	Severe/Complicated	400 mg	q8h	7-14 Days
Nosocomial	Mild/Moderate/Severe	400 mg	q8h	10-14 Days
Pneumonia
Skin and Skin	Mild/Moderate	400 mg	q12h	7-14 Days
Structure	Severe/Complicated	400 mg	q8h	7-14 Days
Bone and Joint	Mild/Moderate	400 mg	q12h	4-6 Weeks
	Severe/Complicated	400 mg	q8h	4-6 Weeks
Intra-Abdominal^	Complicated	400 mg	q12h	7-14 Days
Acute Sinusitis	Mild/Moderate	400 mg	q12h	10 Days
Chronic Bacterial Prostatitis	Mild/Moderate	400 mg	q12h	28 Days
Empirical Therapy in Febrile	Severe Ciprofloxacin	400 mg	q8h
Neutropenic Patients	+ Piperacillin	50 mg/kg	q4h	7-14 Days
		Not to exceed 24 g/day
Inhalational Anthrax (Post-Exposure)^^		400 mg	q12h	60 Days
*DUE TO THE DESIGNATED PATHOGENS ^used in conjunction with metronidazole. (See product labeling for prescribing information.) ^^Drug administration should begin as soon as possible after suspected or confirmed exposure. This indication is based on a surrogate endpoint, ciprofloxacin serum concentrations achieved in humans, reasonably likely to predict clinical benefit.4 For a discussion of ciprofloxacin serum concentrations in various human populations, see INHALATIONAL ANTHRAX — ADDITIONAL INFORMATION. Total duration of ciprofloxacin administration (IV or oral) for inhalational anthrax (post-exposure) is 60 days.

Ciprofloxacin injection should be administered by intravenous infusion over a period of 60 minutes.

Conversion of IV to Oral Dosing in Adults: Ciprofloxacin tablets and oral suspension for oral administration are available. Parenteral therapy may be switched to oral ciprofloxacin when the condition warrants, at the discretion of the physician.

Equivalent AUC Dosing Regimens
Ciprofloxacin Oral Dosage	Equivalent Ciprofloxacin Injection Dosage
250 mg Tablet q 12 h	200 mg IV q 12 h
500 mg Tablet q 12 h	400 mg IV q 12 h
750 mg Tablet q 12 h	400 mg IV q 8 h

Renal Dosing

[CRCL >30 ]: no changes

[5-30 ml/min]:
(IV): 200-400mg q18-24h or give 200mg q12h.
(Oral): 250 q12h or, 250-500mg q18 to 24 hours.

Hemodialysis

(IV): 200-400mg q24h or 200mg q12h. Schedule dose after dialysis on dialysis days.

(Oral): 250mg q12h or 250-500mg q24h. Schedule dose after dialysis on dialysis days.

Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer

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