Caspofungin Acetate Cancidas ®

Usual Diluents

NS

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

[35 to 75 mg/ 250 ml] [1 hour]

Stability / Miscellaneous

Stability: 24 hours RT / REF. Label: Refrigerate.    Storage: Vials are stored in the refrigerator.   Reconstitution: 50 and 70 mg vial: add 10.5 ml normal saline. Transfer 10 ml of the reconstituted solution to 250ml normal saline IV bag. If using two 50mg vials to obtain the 70mg loading dose, add 10.5 ml to each vial and then withdraw 14 ml of the reconstituted solution to 250ml normal saline IV bag.  Patients who are fluid restricted: 50mg dose may be added to 100 ml normal saline.  Hepatic dosing: Patients with moderate hepatic insufficiency should receive 35mg once daily. To prepare this dose, reconstitute the 50mg vial with 10.5 ml and then withdraw 7 ml from the vial and transfer this to 250ml normal saline. Dosing: 70 mg loading on day 1, followed by 50mg once daily thereafter. Patients with moderate hepatic insufficiency should receive the 70mg loading dose on day 1, and then 35mg IV once daily thereafter.  Indications: treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies (ampho B, itraconazole etc.).