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Inflammatory bowel disease - Common medications
balsalazide (Colazal ® ) |
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Indication: treatment of mildly to moderately active
ulcerative colitis. Safety and effectiveness of Colazal ® beyond 12
weeks has not been established. Dosing (Adults): Usual dose: three 750 mg capsules taken three times a day for a total daily dose of 6.75 grams for a duration of 8 weeks. Some patients in the clinical trials required treatment for up to 12 weeks. [Supplied: 750mg capsule] |
budesonide (Entocort EC ® ) |
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Indication: treatment of mild to moderate active
Crohn's disease involving the ileum and/or the ascending colon.
Budesonide has a high topical glucocorticosteroid (GCS) activity and a
substantial first pass elimination. Usual dose ( adults): 9 mg taken once daily in the morning for up to 8 weeks. Safety and efficacy have not been established beyond 8 weeks. For recurring episodes of active Crohn's Disease, a repeat 8 week course of Entocort EC ® can be given. Treatment can be tapered to 6 mg daily for 2 weeks prior to complete cessation. Patients with mild to moderate active Crohn's disease have been switched from oral prednisolone to Entocort EC ® with no reported episodes of adrenal insufficiency. Since prednisolone should not be stopped abruptly, tapering should begin concomitantly with initiating Entocort EC ® treatment. [Supplied: 3 mg capsule] |
infliximab (Remicade ®) |
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Monoclonal antibody to tumor necrosis factor.
Dosing (Adults): TX crohn's disease: 5 mg/kg IV infusion over 2 hrs. In pts with fistulizing disease, an initial 5 mg/kg dose should be followed by additional 5 mg/kg doses at 2 and 6 weeks after the first infusion. |
mesalamine (Asacol ®, Pentasa ®) |
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Indications: remission and treatment of ulcerative
colitis. (Usual course of therapy: 3-6 weeks). Dosing (Adults): (Asacol): 800mg orally three times daily for 3 - 6 weeks [supplied: 400mg tab], (Pentasa): 1000mg orally four times daily for up to 8 weeks. [supplied: 250mg capsule] Rowasa (rectal suspension 4 g/60 ml): one rectal instillation once a day and retained for approximately 8 hours. (usually given at bedtime). (rectal suppository 500mg): Insert one suppository rectally bid. Retained for 1-3 hours. |
olsalazine (Dipentum ® ) |
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Indications: maintenance of remission of ulcerative
colitis in patients intolerant to sulfasalazine.
Dosing (Adults): 500mg orally
twice daily. [Supplied: 250mg capsule]. |
sulfasalazine (Azulfidine ®) |
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Indications: management of ulcerative colitis.
Dosage (adults) initial: 1 gram 3 to 4 times daily. Maintenance: 2 grams/day in divided doses. May initiate therapy with 0.5 to 1 gram/day with enteric-coated tablets. [ Supplied: 500mg tablet, 500mg enteric-coated tablet] |
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any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
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