Anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA). 
Dosing:  Initially, IV bolus: 0.75 mg/kg, followed by an infusion of 1.75 mg/kg/hour for the duration of the procedure.  Determine ACT 5 minutes after bolus dose has been administered.  Continuation of the Angiomax infusion following PCI for up to 4 hours post-procedure is optional, at the discretion of the treating physician. After 4 hours, an additional IV infusion of Angiomax may be initiated at a rate of 0.2 mg/kg/h for up to 20 hours, if needed.