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Patients who receive cotrimoxazole
intravenously or orally and have impaired renal function should be dosed
according to the following dosage schedule:
Creatinine Clearance Dosage (mL/min)
Above 30: Standard regimen
15-30: 1/2 standard regimen
Below 15: Not recommended
Non-PCP:
[>30 ml/min]: no change
[15-30]: 2.5 mg/kg q12h
[<15 ml/min]: not recommended by manufacturer.
Alternative (LESS SUPPORT): 2.5mg/kg q24h (Avoid if possible due to risk of
crystalluria/ nephrolithiasis)
PCP:
[>30 ml/min]: no change
[15-30]: 5mg/kg q12h
[<15 ml/min]: not recommended by manufacturer.
Alternative (LESS SUPPORT): 5mg/kg q24h (Avoid if possible due to risk of
crystalluria/ nephrolithiasis)
Hemodialysis:
Not recommended by manufacturer.
Alternative (LESS SUPPORT):
Oral: Avoid if possible. If unavoidable, give one SS/DS q24h.
IV: Avoid if possible. If unavoidable, give 5mg/kg q24h.
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